Hauke Walter
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Explore the profile of Hauke Walter including associated specialties, affiliations and a list of published articles.
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40
Citations
625
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Recent Articles
1.
Bastys T, Gapsys V, Walter H, Heger E, Doncheva N, Kaiser R, et al.
Retrovirology
. 2020 May;
17(1):13.
PMID: 32430025
Background: HIV-1 can develop resistance to antiretroviral drugs, mainly through mutations within the target regions of the drugs. In HIV-1 protease, a majority of resistance-associated mutations that develop in response...
2.
Heger E, Kaiser R, Knops E, Neumann-Fraune M, Schuelter E, Pironti A, et al.
J Clin Virol
. 2017 Jun;
93:53-56.
PMID: 28633097
Background: Quality Assurance (QA) programs are essential to evaluate performance in diagnostics laboratories. Objectives: We present the results from the first QA for HIV-1 genotypic tropism testing, organized and coordinated...
3.
Pironti A, Pfeifer N, Walter H, Jensen B, Zazzi M, Gomes P, et al.
PLoS One
. 2017 Apr;
12(4):e0174992.
PMID: 28394945
Antiretroviral treatment history and past HIV-1 genotypes have been shown to be useful predictors for the success of antiretroviral therapy. However, this information may be unavailable or inaccurate, particularly for...
4.
Widera M, Dirks M, Bleekmann B, Jablonka R, Daumer M, Walter H, et al.
Med Microbiol Immunol
. 2017 Feb;
206(3):203-215.
PMID: 28220254
After the start of antiretroviral therapy (ART), plasma HIV-RNA levels should fall below the limit of detection (LOD) within 24 weeks. Hence, the prolonged decline of HIV-RNA after ART initiation...
5.
Pironti A, Walter H, Pfeifer N, Knops E, Lubke N, Buch J, et al.
J Acquir Immune Defic Syndr
. 2016 Oct;
74(5):e129-e137.
PMID: 27787339
Background: HIV-1 drug resistance can be measured with phenotypic drug-resistance tests. However, the output of these tests, the resistance factor (RF), requires interpretation with respect to the in vivo activity...
6.
Heger E, Theis A, Remmel K, Walter H, Pironti A, Knops E, et al.
J Virol Methods
. 2016 Oct;
238:29-37.
PMID: 27737783
Phenotypic resistance analysis is an indispensable method for determination of HIV-1 resistance and cross-resistance to novel drug compounds. Since integrase inhibitors are essential components of recent antiretroviral combination therapies, phenotypic...
7.
Kalaghatgi P, Sikorski A, Knops E, Rupp D, Sierra S, Heger E, et al.
PLoS One
. 2016 May;
11(5):e0155869.
PMID: 27196673
The face of hepatitis C virus (HCV) therapy is changing dramatically. Direct-acting antiviral agents (DAAs) specifically targeting HCV proteins have been developed and entered clinical practice in 2011. However, despite...
8.
Obermeier M, Ehret R, Wienbreyer A, Walter H, Berg T, Baumgarten A
J Int AIDS Soc
. 2014 Nov;
17(4 Suppl 3):19756.
PMID: 25397501
Introduction: Proven resistance against HIV drugs, either by phenotyping or genotyping is a rare event in clinical trials. The overall assumption of drug resistance disappearing is additionally driven by the...
9.
Carganico A, Dupke S, Ehret R, Berg T, Baumgarten A, Obermeier M, et al.
J Int AIDS Soc
. 2014 Nov;
17(4 Suppl 3):19749.
PMID: 25397494
Introduction: The most recently approved antiretroviral, the integrase inhibitor dolutegravir (DTG), is described to be a very potent drug with a unique resistance profile, but a certain degree of cross-resistance...
10.
Pironti A, Pfeifer N, Kaiser R, Walter H, Lengauer T
J Int AIDS Soc
. 2014 Nov;
17(4 Suppl 3):19743.
PMID: 25397488
Introduction: Rules-based HIV-1 drug-resistance interpretation (DRI) systems disregard many amino-acid positions of the drug's target protein. The aims of this study are (1) the development of a drug-resistance interpretation system...