Alejandro Pironti
Overview
Explore the profile of Alejandro Pironti including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
491
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Recent Articles
1.
Perault A, John A, DuMont A, Shopsin B, Pironti A, Torres V
Proc Natl Acad Sci U S A
. 2025 Feb;
122(8):e2414315122.
PMID: 39977318
Pathogenic species are of increasing clinical concern due to the multidrug-resistant nature of these bacteria, including resistance to carbapenem antibiotics. Our understanding of virulence is limited, hindering the development of...
2.
Lejeune A, Zhou C, Ercelen D, Putzel G, Yao X, Guy A, et al.
bioRxiv
. 2025 Jan;
PMID: 39763855
Gastrointestinal (GI) colonization by methicillin-resistant (MRSA) is associated with a high risk of transmission and invasive disease in vulnerable populations. The immune and microbial factors that permit GI colonization remain...
3.
Kahne S, Yoo J, Chen J, Nakedi K, Iyer L, Putzel G, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2407239121.
PMID: 39585979
In , proteins that are posttranslationally modified with a prokaryotic ubiquitin-like protein (Pup) can be degraded by bacterial proteasomes. A single Pup-ligase and depupylase shape the pupylome, but the mechanisms...
4.
Bhattacharya M, Spencer B, Kwiecinski J, Podkowik M, Putzel G, Pironti A, et al.
bioRxiv
. 2024 Nov;
PMID: 39554114
causes approximately 80% of skin and soft tissue infections (SSTIs). Collagen is the most abundant human extracellular matrix protein with critical roles in wound healing, and encodes a collagen binding...
5.
Zhou B, Wang C, Putzel G, Hu J, Liu M, Wu F, et al.
Microbiol Spectr
. 2024 Sep;
12(11):e0143124.
PMID: 39311770
Importance: The advancement in DNA-sequencing technology has enabled the high-resolution identification of microorganisms in microbial communities. Since different microbial strains within species may contain extreme phenotypic variability (e.g., nutrition metabolism,...
6.
Lubkin A, Bernard-Raichon L, DuMont A, Valero Jimenez A, Putzel G, Gago J, et al.
mBio
. 2024 Jul;
15(8):e0166724.
PMID: 39037272
Importance: The COVID-19 pandemic has had an enormous impact on healthcare across the globe. Patients who were severely infected with SARS-CoV-2, the virus causing COVID-19, sometimes became infected with other...
7.
Zhou C, Pawline M, Pironti A, Morales S, Perault A, Ulrich R, et al.
bioRxiv
. 2024 May;
PMID: 38766195
Depletion of microbiota increases susceptibility to gastrointestinal colonization and subsequent infection by opportunistic pathogens such as methicillin-resistant (MRSA). How the absence of gut microbiota impacts the evolution of MRSA is...
8.
Podkowik M, Perault A, Putzel G, Pountain A, Kim J, DuMont A, et al.
Elife
. 2024 Apr;
12.
PMID: 38687677
The quorum-sensing system links metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of HO, a crucial host defense against . We now report that...
9.
Ulrich R, Podkowik M, Tierce R, Irnov I, Putzel G, Samhadaneh N, et al.
bioRxiv
. 2024 Apr;
PMID: 38659881
We recently described the evolution of a community-acquired methicillin-resistant (CA-MRSA) USA300 variant responsible for an outbreak of skin and soft tissue infections. Acquisition of a mosaic version of the Φ11...
10.
Kahne S, Yoo J, Chen J, Nakedi K, Iyer L, Putzel G, et al.
bioRxiv
. 2024 Apr;
PMID: 38585835
One Sentence Summary: A pseudo-pantothenate kinase regulates proteasomal degradation of a pantothenate synthesis enzyme in .