Alejandro D Roth
Overview
Explore the profile of Alejandro D Roth including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
409
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Recent Articles
1.
de Faria Jr O, Dhaunchak A, Kamen Y, Roth A, Kuhlmann T, Colman D, et al.
Sci Rep
. 2019 Mar;
9(1):3606.
PMID: 30837646
Oligodendrocyte precursor cells (OPCs) differentiate during postnatal development into myelin-forming oligodendrocytes, in a process distinguished by substantial changes in morphology and the onset of myelin gene expression. A mammalian-specific CNS...
2.
Roth A, Nunez M
Adv Exp Med Biol
. 2016 Oct;
949:167-181.
PMID: 27714689
The study of the metabolic interactions between myelinating glia and the axons they ensheath has blossomed into an area of research much akin to the elucidation of the role of...
3.
Falcon-Urrutia P, Carrasco C, Lois P, Palma V, Roth A
PLoS One
. 2015 Jul;
10(7):e0133567.
PMID: 26218245
Primary Cilia (PC) are a very likely place for signal integration where multiple signaling pathways converge. Two major signaling pathways clearly shown to signal through the PC, Sonic Hedgehog (Shh)...
4.
Munoz Y, Fuenzalida K, Bronfman M, Gatica A, Sepulveda M, Bacigalupo J, et al.
Biol Res
. 2013 Dec;
46(3):289-94.
PMID: 24346077
Phototransduction, the mechanism underlying the electrical response to light in photoreceptor cells, has been thoroughly investigated in Drosophila melanogaster, an essential model in signal transduction research. These cells present a...
5.
Roth A, Liazoghli D, Perez de Arce F, Colman D
Biol Res
. 2013 Dec;
46(3):243-9.
PMID: 24346071
Myelin sheaths present two distinct domains: compacted myelin spirals and flanking non-compacted cytoplasmic channels, where lipid and protein segregation is established by unknown mechanisms. Septins, a conserved family of membrane...
6.
Liazoghli D, Roth A, Thostrup P, Colman D
ACS Chem Neurosci
. 2012 Feb;
3(2):90-95.
PMID: 22348182
Myelination is a highly regulated developmental process whereby oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system ensheathe axons with a multilayered concentric membrane. Axonal...
7.
Dhaunchak A, Huang J, de Faria Junior O, Roth A, Pedraza L, Antel J, et al.
Glia
. 2010 Sep;
58(16):1949-60.
PMID: 20830807
Compact myelin, the paranode, and the juxtaparanode are discrete domains that are formed on myelinated axons. In humans, neurological disorders associated with loss of myelin, including Multiple Sclerosis, often also...
8.
Vincent T, Saikali P, Cayrol R, Roth A, Bar-Or A, Prat A, et al.
J Immunol
. 2008 Oct;
181(8):5730-7.
PMID: 18832732
Autoantibody neuromyelitis optica-IgG (NMO-IgG) recognizing aquaporin-4 (AQP4) is implicated as playing a central role in the physiopathology of NMO. The aim of this in vitro-based study was to characterize functional...
9.
Roth A, Ivanova A, Colman D
Neuron Glia Biol
. 2008 Jul;
2(1):15-21.
PMID: 18634588
Myelin formation and maintenance depends on the establishment of two structurally and biochemically discernible domains: (a)compact myelin, that is multilamellar stacks of plasma membrane sheets; and (b) cytoplasmic channels that...
10.
Golan N, Adamsky K, Kartvelishvily E, Brockschnieder D, Mobius W, Spiegel I, et al.
Glia
. 2008 Jun;
56(11):1176-86.
PMID: 18571792
Oligodendrocytes form an insulating multilamellar structure of compact myelin around axons, which allows efficient and rapid propagation of action potentials. However, little is known about the molecular mechanisms operating at...