Albert W Girotti
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Explore the profile of Albert W Girotti including associated specialties, affiliations and a list of published articles.
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75
Citations
5237
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Recent Articles
1.
Korbelik M, Heger M, Girotti A
J Lipid Res
. 2024 Dec;
66(2):100729.
PMID: 39675508
Hydroperoxides of unsaturated membrane lipids (LOOHs) are the most abundant non-radical intermediates generated by photodynamic therapy (PDT) of soft tissues such as tumors and have far longer average lifetimes than...
2.
Girotti A, Korytowski W
Int J Mol Sci
. 2024 Jun;
25(11).
PMID: 38891885
Anti-tumor photodynamic therapy (PDT) is a unique modality that employs a photosensitizer (PS), PS-exciting light, and O to generate cytotoxic oxidants. For various reasons, not all malignant cells in any...
3.
Pabisz P, Bazak J, Sabat M, Girotti A, Korytowski W
Cell Biochem Biophys
. 2023 Nov;
82(1):213-222.
PMID: 37995086
Trafficking of intracellular cholesterol (Ch) to and into mitochondria of steroidogenic cells is required for steroid hormone biosynthesis. This trafficking is typically mediated by one or more proteins of the...
4.
Bazak J, Korytowski W, Girotti A
Crit Rev Oncog
. 2023 Oct;
28(1):15-25.
PMID: 37824384
When selected tumor cells in a large in vitro population are exposed to ionizing radiation, they can send pro-survival signals to non-exposed counterparts (bystander cells). If there is no physical...
5.
Girotti A, Bazak J, Korytowski W
Int J Mol Sci
. 2023 Jul;
24(14).
PMID: 37511317
Various studies have revealed that several cancer cell types can upregulate inducible nitric oxide synthase (iNOS) and iNOS-derived nitric oxide (NO) after moderate photodynamic treatment (PDT) sensitized by 5-aminolevulinic acid...
6.
Girotti A, Korytowski W
Free Radic Res
. 2023 May;
57(2):130-139.
PMID: 37171212
Lipid hydroperoxides (LOOHs) are reactive intermediates that arise during peroxidation of unsaturated phospholipids, glycolipids and cholesterol in biological membranes and lipoproteins. Non-physiological lipid peroxidation (LPO) typically occurs under oxidative stress...
7.
Girotti A, Fahey J, Korytowski W
Crit Rev Oncol Hematol
. 2022 Sep;
179:103805.
PMID: 36087851
Low level nitric oxide (NO) produced by inducible NO synthase (iNOS) in many malignant tumors is known to play a key role in the survival and proliferation of tumor cells....
8.
Fahey J, Girotti A
Methods Mol Biol
. 2022 May;
2451:21-31.
PMID: 35505007
Numerous studies have shown that low-flux nitric oxide (NO) in tumors produced mainly by inducible nitric oxide synthase (iNOS/NOS2) can signal for angiogenesis, inhibition of apoptosis, and promotion of cell...
9.
Pabisz P, Bazak J, Girotti A, Korytowski W
Biochem Biophys Res Commun
. 2022 Jan;
591:82-87.
PMID: 34999258
Steroid hormone synthesis in steroidogenic cells requires cholesterol (Ch) delivery to/into mitochondria via StAR family trafficking proteins. In previous work, we discovered that 7-OOH, an oxidative stress-induced cholesterol hydroperoxide, can...
10.
Girotti A, Korytowski W
Photochem Photobiol
. 2021 Oct;
98(3):591-597.
PMID: 34633674
Lipid hydroperoxides (LOOHs), including cholesterol- and phospholipid-derived species, are reactive intermediates that arise during photosensitized peroxidation of unsaturated lipids in biological membranes. These intermediates may appear in cancer cell membranes...