Albert Jeltsch
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Explore the profile of Albert Jeltsch including associated specialties, affiliations and a list of published articles.
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251
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8103
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Recent Articles
1.
Sogl G, Pilling S, Fischer L, Ludwig J, Mihretu N, Bashtrykov P, et al.
Nucleic Acids Res
. 2025 Mar;
53(5).
PMID: 40037710
DNA-(cytosine C5)-methyltransferases (MTases) represent a large group of evolutionary related enzymes with specific DNA interaction. We systematically investigated the specificity and flanking sequence preferences of six bacterial enzymes of this...
2.
Chandrasekaran T, Choudalakis M, Brohm A, Weirich S, Kouroukli A, Ammerpohl O, et al.
Nucleic Acids Res
. 2024 Nov;
52(22):13690-13705.
PMID: 39540436
SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a major protein lysine methyltransferase trimethylating lysine 9 on histone H3 (H3K9) which is involved in heterochromatin formation and silencing of...
3.
Rajaram N, Benzler K, Bashtrykov P, Jeltsch A
iScience
. 2024 Oct;
27(10):111007.
PMID: 39429790
Epigenome editing is an emerging technology that allows to rewrite epigenome states and reprogram gene expression. Here, we have developed allele-specific DNA demethylation editing at gene promoters containing an SNP...
4.
Albrecht C, Bashtrykov P, Jeltsch A
Methods Mol Biol
. 2024 Jul;
2842:405-418.
PMID: 39012608
DNA methylation is an important epigenetic modification that regulates chromatin structure and the cell-type-specific expression of genes. The association of aberrant DNA methylation with many diseases, as well as the...
5.
Rajaram N, Bashtrykov P, Jeltsch A
Methods Mol Biol
. 2024 Jul;
2842:179-192.
PMID: 39012596
The discovery and adaptation of CRISPR/Cas systema for epigenome editing has allowed for a straightforward design of targeting modules that can direct epigenome editors to virtually any genomic site. This...
6.
Rots M, Jeltsch A
Methods Mol Biol
. 2024 Jul;
2842:3-20.
PMID: 39012588
The introduction of CRISPR/Cas systems has resulted in a strong impulse for the field of gene-targeted epigenome/epigenetic reprogramming (EpiEditing), where EpiEditors consisting of a DNA binding part for targeting and...
7.
Weirich S, Kusevic D, Schnee P, Reiter J, Pleiss J, Jeltsch A
Commun Biol
. 2024 Jun;
7(1):707.
PMID: 38851815
The human protein lysine methyltransferase NSD2 catalyzes dimethylation at H3K36. It has very important roles in development and disease but many mechanistic features and its full spectrum of substrate proteins...
8.
Dossmann L, Emperle M, Dukatz M, de Mendoza A, Bashtrykov P, Jeltsch A
Commun Biol
. 2024 May;
7(1):582.
PMID: 38755427
The DNA methyltransferase DNMT3C appeared as a duplication of the DNMT3B gene in muroids and is required for silencing of young retrotransposons in the male germline. Using specialized assay systems,...
9.
Yamaguchi K, Chen X, Rodgers B, Miura F, Bashtrykov P, Bonhomme F, et al.
Nat Commun
. 2024 Apr;
15(1):2960.
PMID: 38580649
DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It is yet unclear if UHRF1 functions solely by stimulating DNA methylation maintenance...
10.
Choudalakis M, Bashtrykov P, Jeltsch A
Mob DNA
. 2024 Apr;
15(1):6.
PMID: 38570859
Background: Repeat elements (REs) play important roles for cell function in health and disease. However, RE enrichment analysis in short-read high-throughput sequencing (HTS) data, such as ChIP-seq, is a challenging...