Srikanth Kudithipudi
Overview
Explore the profile of Srikanth Kudithipudi including associated specialties, affiliations and a list of published articles.
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29
Citations
789
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Recent Articles
1.
Weirich S, Schuhmacher M, Kudithipudi S, Lungu C, Ferguson A, Jeltsch A
Chembiochem
. 2019 Oct;
21(1-2):256-264.
PMID: 31612581
The SMYD2 protein lysine methyltransferase methylates various histone and non-histone proteins and is overexpressed in several cancers. Using peptide arrays, we investigated the substrate specificity of the enzyme, revealing a...
2.
Brohm A, Elsawy H, Rathert P, Kudithipudi S, Schoch T, Schuhmacher M, et al.
J Mol Biol
. 2019 Jul;
431(17):3068-3080.
PMID: 31255706
SUV420H1 is a protein lysine methyltransferase that introduces di- and trimethylation of H4K20 and is frequently mutated in human cancers. We investigated the functional effects of eight somatic cancer mutations...
3.
Jakobsson M, Malecki J, Halabelian L, Nilges B, Pinto R, Kudithipudi S, et al.
Nat Commun
. 2018 Aug;
9(1):3411.
PMID: 30143613
Eukaryotic elongation factor 1 alpha (eEF1A) delivers aminoacyl-tRNA to the ribosome and thereby plays a key role in protein synthesis. Human eEF1A is subject to extensive post-translational methylation, but several...
4.
Schuhmacher M, Rolando M, Brohm A, Weirich S, Kudithipudi S, Buchrieser C, et al.
J Mol Biol
. 2018 May;
430(13):1912-1925.
PMID: 29733858
RomA is a SET-domain containing protein lysine methyltransferase encoded by the Gram-negative bacterium Legionella pneumophila. It is exported into human host cells during infection and has been previously shown to...
5.
Halby L, Marechal N, Pechalrieu D, Cura V, Franchini D, Faux C, et al.
Philos Trans R Soc Lond B Biol Sci
. 2018 Apr;
373(1748).
PMID: 29685976
DNA, RNA and histone methylation is implicated in various human diseases such as cancer or viral infections, playing a major role in cell process regulation, especially in modulation of gene...
6.
Jurkowska R, Qin S, Kungulovski G, Tempel W, Liu Y, Bashtrykov P, et al.
Nat Commun
. 2017 Dec;
8(1):2057.
PMID: 29234025
SETDB1 is an essential H3K9 methyltransferase involved in silencing of retroviruses and gene regulation. We show here that its triple Tudor domain (3TD) specifically binds to doubly modified histone H3...
7.
Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, et al.
Mol Cell
. 2017 Aug;
67(4):550-565.e5.
PMID: 28803780
DNA methylation is an essential epigenetic mark in mammals that has to be re-established after each round of DNA replication. The protein UHRF1 is essential for this process; it has...
8.
Weirich S, Kudithipudi S, Jeltsch A
Mol Oncol
. 2017 Feb;
11(4):373-387.
PMID: 28182322
Somatic missense mutations in the mixed lineage leukemia 1 (MLL1) histone H3K4 methyltransferase are often observed in cancers. MLL1 forms a complex with WDR5, RBBP5, and ASH2L (WRA) which stimulates...
9.
Kudithipudi S, Schuhmacher M, Kebede A, Jeltsch A
ACS Chem Biol
. 2017 Feb;
12(4):958-968.
PMID: 28169523
SUV39H1 is an H3K9 methyltransferase involved in the formation of heterochromatin. We investigated its substrate specificity profile and show recognition of H3 residues between K4 and G12 with highly specific...
10.
Kusevic D, Kudithipudi S, Iglesias N, Moazed D, Jeltsch A
Biochimie
. 2017 Feb;
135:83-88.
PMID: 28143796
In fission yeast, the catalytic activity of the protein lysine methyltransferase (PKMT) Clr4, the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, majorly contributes to the formation of heterochromatin....