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Albebson L Lim

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Articles 9
Citations 37
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Recent Articles
1.
Moos P, Carey A, Joseph J, Kialo S, Norrie J, Moyarelce J, et al.
bioRxiv . 2024 Sep; PMID: 39229107
(Mtb) remains a global human health threat and a significant cause of human morbidity and mortality. We document here the capture of Mtb transcripts in libraries designed to amplify eukaryotic...
2.
Moos P, Carey A, Joseph J, Kialo S, Norrie J, Moyarelce J, et al.
bioRxiv . 2024 Jun; PMID: 38853908
We successfully employed a single cell RNA sequencing (scRNA-seq) approach to describe the cells and the communication networks characterizing granulomatous lymph nodes of TB patients. When mapping cells from individual...
3.
Lim A, Miller B, Lin Z, Fisher M, Barrows L, Haygood M, et al.
Microbiol Spectr . 2023 Oct; 11(6):e0230623. PMID: 37882570
Bacterial resistance to antibiotics is a crisis. is among the CDC urgent threat pathogens in part for this reason. Lipopeptides known as turnercyclamycins are produced by symbiotic bacteria that normally...
4.
Lim A, Moos P, Pond C, Larson E, Martins L, Szaniawski M, et al.
Virulence . 2022 Feb; 13(1):386-413. PMID: 35166645
HIV-1 cDNA pre-integration complexes persist for weeks in macrophages and remain transcriptionally active. While previous work has focused on the transcription of HIV-1 genes; our understanding of the cellular milieu...
5.
Paguigan N, Yan Y, Karthikeyan M, Chase K, Carter J, Leavitt L, et al.
ACS Chem Biol . 2021 Aug; 16(9):1654-1662. PMID: 34423964
Marine tunicates produce defensive amino-acid-derived metabolites, including 2-(3,5-diiodo-4-methoxyphenyl)ethan-1-amine (DIMTA), but their mechanisms of action are rarely known. Using an assay-guided approach, we found that out of the many different sensory...
6.
Paguigan N, Tun J, Leavitt L, Lin Z, Chase K, Dowell C, et al.
ACS Chem Neurosci . 2021 Jul; 12(14):2693-2704. PMID: 34213884
In our efforts to discover new drugs to treat pain, we identified molleamines A-E (-) as major neuroactive components of the sea slug, , and their prey, , tunicates. The...
7.
Miller B, Lim A, Lin Z, Bailey J, Aoyagi K, Fisher M, et al.
Cell Chem Biol . 2021 Jun; 28(11):1628-1637.e4. PMID: 34146491
Teredinibacter turnerae is an intracellular bacterial symbiont in the gills of wood-eating shipworms, where it is proposed to use antibiotics to defend itself and its animal host. Several biosynthetic gene...
8.
Larson E, Lim A, Pond C, Craft M, cavuzic M, Waldrop G, et al.
PLoS One . 2020 May; 15(5):e0233485. PMID: 32470050
Antimicrobial resistance is a growing global health and economic concern. Current antimicrobial agents are becoming less effective against common bacterial infections. We previously identified pyrrolocins A and C, which showed...
9.
Lacerna 2nd N, Miller B, Lim A, Tun J, Robes J, Cleofas M, et al.
J Nat Prod . 2019 Feb; 82(4):1024-1028. PMID: 30793902
Three new pyoluteorin analogues, mindapyrroles A-C (1-3), were purified from Pseudomonas aeruginosa strain 1682U.R.0a.27, a gill-associated bacterium isolated from the tissue homogenate of the giant shipworm Kuphus polythalamius. Mindapyrroles B...