Louis R Barrows
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Explore the profile of Louis R Barrows including associated specialties, affiliations and a list of published articles.
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47
Citations
517
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Recent Articles
1.
Moos P, Carey A, Joseph J, Kialo S, Norrie J, Moyarelce J, et al.
bioRxiv
. 2024 Sep;
PMID: 39229107
(Mtb) remains a global human health threat and a significant cause of human morbidity and mortality. We document here the capture of Mtb transcripts in libraries designed to amplify eukaryotic...
2.
Moos P, Carey A, Joseph J, Kialo S, Norrie J, Moyarelce J, et al.
bioRxiv
. 2024 Jun;
PMID: 38853908
We successfully employed a single cell RNA sequencing (scRNA-seq) approach to describe the cells and the communication networks characterizing granulomatous lymph nodes of TB patients. When mapping cells from individual...
3.
Lim A, Miller B, Lin Z, Fisher M, Barrows L, Haygood M, et al.
Microbiol Spectr
. 2023 Oct;
11(6):e0230623.
PMID: 37882570
Bacterial resistance to antibiotics is a crisis. is among the CDC urgent threat pathogens in part for this reason. Lipopeptides known as turnercyclamycins are produced by symbiotic bacteria that normally...
4.
Praparatana R, Maliyam P, Barrows L, Puttarak P
Molecules
. 2022 Apr;
27(8).
PMID: 35458587
Bioactive compounds from medicinal plants are good alternative treatments for T2DM. They are also sources of lead molecules that could lead to new drug discoveries. In this study, Craib. stem,...
5.
Lim A, Moos P, Pond C, Larson E, Martins L, Szaniawski M, et al.
Virulence
. 2022 Feb;
13(1):386-413.
PMID: 35166645
HIV-1 cDNA pre-integration complexes persist for weeks in macrophages and remain transcriptionally active. While previous work has focused on the transcription of HIV-1 genes; our understanding of the cellular milieu...
6.
Larragoite E, Nell R, Martins L, Barrows L, Planelles V, Spivak A
Biochem Pharmacol
. 2021 Nov;
195:114844.
PMID: 34801521
Latency reversing agents (LRAs), such as protein kinase C (PKC) agonists, constitute a promising strategy for exposing and eliminating the HIV-1 latent reservoir. PKC agonists activate NF-κB and induce deleterious...
7.
Miller B, Lim A, Lin Z, Bailey J, Aoyagi K, Fisher M, et al.
Cell Chem Biol
. 2021 Jun;
28(11):1628-1637.e4.
PMID: 34146491
Teredinibacter turnerae is an intracellular bacterial symbiont in the gills of wood-eating shipworms, where it is proposed to use antibiotics to defend itself and its animal host. Several biosynthetic gene...
8.
Larson E, Lim A, Pond C, Craft M, cavuzic M, Waldrop G, et al.
PLoS One
. 2020 May;
15(5):e0233485.
PMID: 32470050
Antimicrobial resistance is a growing global health and economic concern. Current antimicrobial agents are becoming less effective against common bacterial infections. We previously identified pyrrolocins A and C, which showed...
9.
Serrano C, Kanna Reddy H, Eiler D, Koch M, Tresco B, Barrows L, et al.
Angew Chem Int Ed Engl
. 2020 Apr;
59(28):11330-11333.
PMID: 32342623
In search of new anti-tuberculars compatible with anti-retroviral therapy we re-identified amicetin as a lead compound. Amicetin's binding to the 70S ribosomal subunit of Thermus thermophilus (Tth) has been unambiguously...
10.
Smith T, Pond C, Pierce E, Harmer Z, Kwan J, Zachariah M, et al.
Nat Chem Biol
. 2018 Jan;
14(2):179-185.
PMID: 29291350
Chemistry drives many biological interactions between the microbiota and host animals, yet it is often challenging to identify the chemicals involved. This poses a problem, as such small molecules are...