Eric W Schmidt
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Explore the profile of Eric W Schmidt including associated specialties, affiliations and a list of published articles.
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Articles
127
Citations
4388
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Recent Articles
1.
Sung Y, Miller B, Schmidt E
Org Lett
. 2025 Feb;
27(8):1774-1778.
PMID: 39961138
Teredinibactins are β-resorcyclic thiazoline dipeptides synthesized by T7901, a bacterial symbiont of shipworms in the sea. Through feeding studies, we show that the thiazoline moiety is made from glutathione and...
2.
Venugopalan A, Schmidt E
J Am Chem Soc
. 2025 Feb;
147(8):6623-6632.
PMID: 39933076
The bursatellin-oxazinin family is a series of tyrosine-derived, nitrile-containing marine natural products from gastropod and bivalve molluscs. Although the first analogs were identified and associated with toxicity 40 years ago,...
3.
Schubert H, Li F, Hill C, Schmidt E
Proc Natl Acad Sci U S A
. 2025 Feb;
122(6):e2419884122.
PMID: 39913209
The polyketide synthases (PKSs) in microbes and the cytoplasmic fatty acid synthases in humans (FASs) are related enzymes that have been well studied. As a result, there is a paradigm...
4.
Scesa P, Schmidt E
J Am Chem Soc
. 2025 Jan;
147(4):3072-3079.
PMID: 39818847
Soft corals are prolific producers of terpenoids, such as pseudopterosins. The exact biosynthetic pathway of these anti-inflammatory diterpene glycosides has eluded the scientific community for decades. Using a forward genetic...
5.
Venugopalan A, Schmidt E
bioRxiv
. 2024 Nov;
PMID: 39605576
The bursatellin-oxazinin family is a series of tyrosine-derived, nitrile-containing marine natural products from gastro-pod and bivalve molluscs. Although the first analogs were identified and associated with toxicity forty years ago,...
6.
Scesa P, Nguyen H, Weiss P, Rodriguez A, Garchow M, Ohlemacher S, et al.
Sci Adv
. 2024 Oct;
10(44):eadp8643.
PMID: 39475615
Secondary metabolites often function as antipredator defenses, but when bioactive at low concentrations, their off-target effects on other organisms may be overlooked. Candidate "keystone molecules" are proposed to affect community...
7.
Li F, Lin Z, Schmidt E
iScience
. 2024 Sep;
27(9):110834.
PMID: 39310768
The varied pigments found in animals play both ecological and physiological roles. Virtually all echinoderms contain putative pigment biosynthetic enzymes, the polyketide synthases (PKSs). Among these, crinoids have complex pigments...
8.
Scesa P, Schmidt E
Methods Enzymol
. 2024 Jun;
699:373-394.
PMID: 38942511
Coral terpenes are important molecules with numerous applications. Here, we describe a robust and simple method to produce coral terpene scaffolds at scale. As an example of the approach, here...
9.
Lin Z, Agarwal V, Cong Y, Pomponi S, Schmidt E
Proc Natl Acad Sci U S A
. 2024 Mar;
121(11):e2314383121.
PMID: 38442178
Sponges (Porifera) contain many peptide-specialized metabolites with potent biological activities and significant roles in shaping marine ecology. It is well established that symbiotic bacteria produce bioactive "sponge" peptides, both on...
10.
Lacerna 2nd N, Cong Y, Schmidt E
ACS Synth Biol
. 2024 Jan;
13(1):394-401.
PMID: 38194299
Peptide cyclization improves conformational rigidity, providing favorable pharmacological properties, such as proteolytic resistance, target specificity, and membrane permeability. Thus, many synthetic and biosynthetic peptide circularization strategies have been developed. PatG...