Alastair M Kilpatrick
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Explore the profile of Alastair M Kilpatrick including associated specialties, affiliations and a list of published articles.
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17
Citations
155
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Recent Articles
1.
Candela M, Addison M, Aird R, Man T, Cartwright J, Ashmore-Harris C, et al.
NPJ Regen Med
. 2025 Jan;
10(1):5.
PMID: 39843512
Acute liver failure is a rapidly progressing, life-threatening condition most commonly caused by an overdose of acetaminophen (paracetamol). The antidote, N-acetylcysteine (NAC), has limited efficacy when liver injury is established....
2.
Brennan P, MacMillan M, Manship T, Moroni F, Glover A, Troland D, et al.
Nat Med
. 2025 Jan;
PMID: 39794616
Cirrhosis is a major cause of morbidity and mortality; however, there are no approved therapies except orthotopic liver transplantation. Preclinical studies showed that bone-marrow-derived macrophage injections reduce inflammation, resolve fibrosis...
3.
Gadd V, Ferreira-Gonzalez S, Man T, Kilpatrick A, Aird R, Smith I, et al.
J Hepatol
. 2025 Jan;
PMID: 39755157
Background & Aims: Hepatocyte transplantation has shown promise for genetic diseases of the hepatocytes but to date has shown limited efficacy for non-genetic forms of severe liver injury. Limited cell...
4.
Selem-Mojica N, Karakulak T, Anjum A, Pashkov A, Perez-Estrada R, Enriquez-Guillen K, et al.
Bioinformatics
. 2024 Jun;
40(Suppl 1):i11-i19.
PMID: 38940154
Motivation: Wikipedia is a vital open educational resource in computational biology. The quality of computational biology coverage in English-language Wikipedia has improved steadily in recent years. However, there is an...
5.
Gonzalez Galofre Z, Kilpatrick A, Marques M, Sa da Bandeira D, Ventura T, Gomez Salazar M, et al.
Nat Commun
. 2024 Feb;
15(1):1653.
PMID: 38395882
Hematopoietic stem cells (HSCs) produce all essential cellular components of the blood. Stromal cell lines supporting HSCs follow a vascular smooth muscle cell (vSMC) differentiation pathway, suggesting that some hematopoiesis-supporting...
6.
Seeker L, Bestard-Cuche N, Jakel S, Kazakou N, Bostrand S, Wagstaff L, et al.
Acta Neuropathol Commun
. 2023 May;
11(1):84.
PMID: 37217978
The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are often differentially affected in human neurodegenerative diseases across CNS...
7.
Ferreira-Gonzalez S, Man T, Esser H, Aird R, Kilpatrick A, Rodrigo-Torres D, et al.
Sci Transl Med
. 2022 Dec;
14(674):eabj4375.
PMID: 36475903
Liver transplantation is the only curative option for patients with end-stage liver disease. Despite improvements in surgical techniques, nonanastomotic strictures (characterized by the progressive loss of biliary tract architecture) continue...
8.
Kilpatrick A, Rahman F, Anjum A, Shome S, Andalib K, Banik S, et al.
Bioinformatics
. 2022 Jun;
38(Suppl 1):i19-i27.
PMID: 35758800
Motivation: Wikipedia is one of the most important channels for the public communication of science and is frequently accessed as an educational resource in computational biology. Joint efforts between the...
9.
Kapeni C, Nitsche L, Kilpatrick A, Wilson N, Xia K, Mirshekar-Syahkal B, et al.
Blood
. 2022 Jun;
140(5):464-477.
PMID: 35653588
Hematopoietic stem cells (HSCs) are of major clinical importance, and finding methods for their in vitro generation is a prime research focus. We show here that the cell cycle inhibitor...
10.
Hallett J, Ferreira-Gonzalez S, Man T, Kilpatrick A, Esser H, Thirlwell K, et al.
Cell Stem Cell
. 2022 Mar;
29(3):355-371.e10.
PMID: 35245467
Biliary diseases can cause inflammation, fibrosis, bile duct destruction, and eventually liver failure. There are no curative treatments for biliary disease except for liver transplantation. New therapies are urgently required....