Alastair J OBrien
Overview
Explore the profile of Alastair J OBrien including associated specialties, affiliations and a list of published articles.
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12
Citations
566
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Recent Articles
1.
Aithal G, Palaniyappan N, China L, Harmala S, Macken L, Ryan J, et al.
Gut
. 2020 Oct;
70(1):9-29.
PMID: 33067334
The British Society of Gastroenterology in collaboration with British Association for the Study of the Liver has prepared this document. The aim of this guideline is to review and summarise...
2.
Bernardi M, Angeli P, Claria J, Moreau R, Gines P, Jalan R, et al.
Gut
. 2020 Feb;
69(6):1127-1138.
PMID: 32102926
The pathophysiological background of decompensated cirrhosis is characterised by a systemic proinflammatory and pro-oxidant milieu that plays a major role in the development of multiorgan dysfunction. Such abnormality is mainly...
3.
Maini A, George M, Motwani M, Day R, Gilroy D, OBrien A
PLoS One
. 2016 Oct;
11(10):e0165502.
PMID: 27780229
Defects in neutrophil function have been implicated in a wide spectrum of clinical conditions. Several models are employed to study activated human neutrophils akin to those found at a site...
4.
Vergis N, Khamri W, Beale K, Sadiq F, Aletrari M, Moore C, et al.
Gut
. 2016 Feb;
66(3):519-529.
PMID: 26860769
Objective: In order to explain the increased susceptibility to serious infection in alcoholic hepatitis, we evaluated monocyte phagocytosis, aberrations of associated signalling pathways and their reversibility, and whether phagocytic defects...
5.
China L, Muirhead N, Skene S, Shabir Z, De Maeyer R, Maini A, et al.
BMJ Open
. 2016 Jan;
6(1):e010132.
PMID: 26810999
Introduction: Circulating prostaglandin E2 levels are elevated in acutely decompensated cirrhosis and have been shown to contribute to immune suppression. Albumin binds and inactivates this hormone. Human albumin solution could...
6.
OBrien A, Fullerton J, Massey K, Auld G, Sewell G, James S, et al.
Nat Med
. 2014 Apr;
20(5):518-23.
PMID: 24728410
Liver disease is one of the leading causes of death worldwide. Patients with cirrhosis display an increased predisposition to and mortality from infection due to multimodal defects in the innate...
7.
Fullerton J, OBrien A, Gilroy D
Trends Immunol
. 2013 Nov;
35(1):12-21.
PMID: 24268519
Sepsis, trauma, burns, and major surgical procedures activate common systemic inflammatory pathways. Nosocomial infection, organ failure, and mortality in this patient population are associated with a quantitatively different reprioritization of...
8.
Fullerton J, OBrien A, Gilroy D
J Pathol
. 2013 Jun;
231(1):8-20.
PMID: 23794437
Patients with critical illness, and in particular sepsis, are now recognized to undergo unifying, pathogenic disturbances of immune function. Whilst scientific and therapeutic focus has traditionally been on understanding and...
9.
Alazawi W, Heath H, A Waters J, Woodfin A, OBrien A, Scarzello A, et al.
Proc Natl Acad Sci U S A
. 2013 May;
110(21):8656-61.
PMID: 23653476
Deregulated Toll-like receptor (TLR)-triggered inflammatory responses that depend on NF-κB are detrimental to the host via excessive production of proinflammatory cytokines, including TNF-α. Stat2 is a critical component of type...
10.
OBrien A, Welch C, Singer M, Harrison D
Intensive Care Med
. 2012 Mar;
38(6):991-1000.
PMID: 22456768
Purpose: Patients with decompensated liver cirrhosis who are admitted to intensive care units (ICU) are perceived, within the UK, as having a particularly poor prognosis. Methods: We performed a descriptive...