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» Authors » Alastair J OBrien

Alastair J OBrien

Explore the profile of Alastair J OBrien including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 566
Followers 0
Related Specialties
General Medicine
Gastroenterology
Science
Top 10 Co-Authors
Derek W Gilroy
James N Fullerton
Mervyn Singer
Lucie H Clapp
Sarah James
Jennifer M Ryan
Graham R Foster
Louise China
William Alazawi
Gemma Petts
Published In
Gut
Br J Pharmacol
Proc Natl Acad Sci U S A
Nat Med
PLoS One
Affiliations
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Recent Articles
11.
BK large conductance Ca²+-activated K+ channel-deficient mice are not resistant to hypotension and display reduced survival benefit following polymicrobial sepsis
OBrien A, Terala D, Orie N, Davies N, Zolfaghari P, Singer M, et al.
Shock . 2011 Feb; 35(5):485-91. PMID: 21330953
Nitric oxide-mediated activation of large conductance calcium-activated potassium (BK) channels is considered an important underlying mechanism of sepsis-induced hypotension. Indeed, the nonselective K-channel inhibitor, tetraethylammonium chloride (TEA), has been proposed...
12.
The pore-forming subunit of the K(ATP) channel is an important molecular target for LPS-induced vascular hyporeactivity in vitro
OBrien A, Thakur G, Buckley J, Singer M, Clapp L
Br J Pharmacol . 2005 Jan; 144(3):367-75. PMID: 15655519
ATP-sensitive K(+) (K(ATP)) channel activation is implicated in the vascular hyporeactivity occurring in septic shock. However, channel inhibition with the sulphonylurea receptor (SUR) antagonist, glibenclamide (Glib) fails to reverse lipopolysaccharide...