Alan C Opsahl
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Explore the profile of Alan C Opsahl including associated specialties, affiliations and a list of published articles.
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12
Citations
306
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Recent Articles
1.
Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems
Ross T, Crowley C, Kelly K, Rinaldi A, Beebe D, Lech M, et al.
Cell Mol Gastroenterol Hepatol
. 2020 Jun;
10(4):829-851.
PMID: 32526482
Background & Aims: Disordered metabolism, steatosis, hepatic inflammation, and fibrosis contribute to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl-CoA carboxylase (ACC) catalyzes the first committed step in de novo lipogenesis...
2.
Zhong X, Jagarlapudi S, Weng Y, Ly M, Rouse J, McClure K, et al.
J Biol Chem
. 2020 Feb;
295(10):3115-3133.
PMID: 32005658
The fortuitously discovered antiaging membrane protein αKlotho (Klotho) is highly expressed in the kidney, and deletion of the gene in mice causes a phenotype strikingly similar to that of chronic...
3.
Walters K, Boucher M, Boucher G, Opsahl A, Mouton P, Liu C, et al.
Toxicol Pathol
. 2019 Apr;
48(1):228-237.
PMID: 30987556
The potential for neurogenesis in the cranial (superior) cervical ganglia (SCG) of the sympathetic nervous system was evaluated. Eleven consecutive daily doses of guanethidine (100 mg/kg/d) were administered intraperitoneally to...
4.
Flach R, Su C, Bollinger E, Cortes C, Robertson A, Opsahl A, et al.
PLoS One
. 2019 Mar;
14(3):e0214150.
PMID: 30889221
Myeloperoxidase (MPO) is a highly abundant protein within the neutrophil that is associated with lipoprotein oxidation, and increased plasma MPO levels are correlated with poor prognosis after myocardial infarct. Thus,...
5.
Cook J, Obert L, Koza-Taylor P, Coskran T, Opsahl A, Ziemek D, et al.
Toxicol Sci
. 2017 Oct;
161(1):58-75.
PMID: 28973697
Pharmaceuticals and chemicals produce hemangiosarcomas (HS) in mice, often by nongenotoxic, proliferative mechanisms. A mode-of-action (MOA) for hemangiosarcoma was proposed based on information presented at an international workshop (Cohen et...
6.
Cokorinos E, Delmore J, Reyes A, Albuquerque B, Kjobsted R, Jorgensen N, et al.
Cell Metab
. 2017 May;
25(5):1147-1159.e10.
PMID: 28467931
The AMP-activated protein kinase (AMPK) is a potential therapeutic target for metabolic diseases based on its reported actions in the liver and skeletal muscle. We evaluated two distinct direct activators...
7.
Salatto C, Miller R, Cameron K, Cokorinos E, Reyes A, Ward J, et al.
J Pharmacol Exp Ther
. 2017 Mar;
361(2):303-311.
PMID: 28289077
Diabetic nephropathy remains an area of high unmet medical need, with current therapies that slow down, but do not prevent, the progression of disease. A reduced phosphorylation state of adenosine...
8.
Zahner M, Liu C, Okerberg C, Opsahl A, Bobrowski W, Somps C
J Pharmacol Toxicol Methods
. 2016 Apr;
80:59-67.
PMID: 27085835
The goal of this study was to determine the degree of sympathetic postganglionic neuronal loss required to impair cardiovascular-related sympathetic activity. To produce neuronal loss separate groups of rats were...
9.
High throughput object-based image analysis of β-amyloid plaques in human and transgenic mouse brain
Samaroo H, Opsahl A, Schreiber J, ONeill S, Marconi M, Qian J, et al.
J Neurosci Methods
. 2011 Oct;
204(1):179-188.
PMID: 22019329
Advances in imaging technology have enabled automated approaches for quantitative image analysis. In this study, a high content object based image analysis method was developed for quantification of β-amyloid (Aβ)...
10.
Bernardo B, Wachtmann T, Cosgrove P, Kuhn M, Opsahl A, Judkins K, et al.
PLoS One
. 2010 Jul;
5(6):e11307.
PMID: 20593012
Background: Interventions for T2DM have in part aimed to mimic exercise. Here, we have compared the independent and combined effects of a PPARdelta agonist and endurance training mimetic (GW501516) and...