Alagarsamy L Reddi
Overview
Explore the profile of Alagarsamy L Reddi including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
299
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0
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Recent Articles
1.
Biyashev D, Veliceasa D, Topczewski J, Topczewska J, Mizgirev I, Vinokour E, et al.
Blood
. 2011 Dec;
119(11):2679-87.
PMID: 22207734
We discovered that miR-27b controls 2 critical vascular functions: it turns the angiogenic switch on by promoting endothelial tip cell fate and sprouting and it promotes venous differentiation. We have...
2.
Duan L, Raja S, Chen G, Virmani S, Williams S, Clubb R, et al.
J Biol Chem
. 2010 Oct;
286(1):620-33.
PMID: 20940296
The E3 ubiquitin ligase Casitas B lymphoma protein (Cbl) controls the ubiquitin-dependent degradation of EGF receptor (EGFR), but its role in regulating downstream signaling elements with which it associates and...
3.
Akbulut S, Reddi A, Aggarwal P, Ambardekar C, Canciani B, Kim M, et al.
Mol Biol Cell
. 2010 Aug;
21(19):3487-96.
PMID: 20719962
Sprouty (Spry) proteins are negative regulators of receptor tyrosine kinase signaling; however, their exact mechanism of action remains incompletely understood. We identified phosphatidylinositol-specific phospholipase C (PLC)-γ as a partner of...
4.
Duan L, Chen G, Virmani S, Ying G, Raja S, Chung B, et al.
J Biol Chem
. 2009 Oct;
285(2):1555-68.
PMID: 19826000
Non-malignant mammary epithelial cells (MECs) undergo acinar morphogenesis in three-dimensional Matrigel culture, a trait that is lost upon oncogenic transformation. Rho GTPases are thought to play important roles in regulating...
5.
Zhang M, Veselits M, ONeill S, Hou P, Reddi A, Berlin I, et al.
J Immunol
. 2007 Sep;
179(7):4435-43.
PMID: 17878339
In both infection and autoimmunity, the development of high-affinity Abs and memory requires B cells to efficiently capture and process Ags for presentation to cognate T cells. Although a great...
6.
Ghosh A, Reddi A, Rao N, Duan L, Band V, Band H
J Biol Chem
. 2004 Jun;
279(34):36132-41.
PMID: 15208330
Members of the Cbl family of ubiquitin ligases have emerged as crucial negative regulators of tyrosine kinase signaling. These proteins preferentially interact with and target activated tyrosine kinases for ubiquitinylation,...
7.
Miura-Shimura Y, Duan L, Rao N, Reddi A, Shimura H, Rottapel R, et al.
J Biol Chem
. 2003 Jul;
278(40):38495-504.
PMID: 12881521
The Cbl ubiquitin ligase has emerged as a negative regulator of receptor and non-receptor tyrosine kinases. Cbl is known to associate with the proto-oncogene product Vav, a hematopoietic-restricted Rac guanine...
8.
Duan L, Miura Y, Dimri M, Majumder B, Dodge I, Reddi A, et al.
J Biol Chem
. 2003 May;
278(31):28950-60.
PMID: 12754251
Ligand-induced down-regulation controls the signaling potency of the epidermal growth factor receptor (EGFR/ErbB1). Overexpression studies have identified Cbl-mediated ubiquitinylation of EGFR as a mechanism of ligand-induced EGFR down-regulation. However, the...