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» Authors » Alaa M Hayallah

Alaa M Hayallah

Explore the profile of Alaa M Hayallah including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 37
Citations 526
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
Bahaa G M Youssif
Mohamed Abdel-Aziz
Gamal El-Din A Abuo-Rahma
Usama Ramadan Abdelmohsen
Anber F Mohammed
Dalia Abdelhamid
Yaser A Mostafa
Muhamad Mustafa
Hesham A Abou-Zied
Christa E Muller
Published In
Bioorg Chem
Pharmaceuticals (Basel)
Nat Prod Res
RSC Adv
J Med Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Design, Synthesis, and Antiproliferative Activity of Novel Indole/1,2,4-Triazole Hybrids as Tubulin Polymerization Inhibitors
Mahmoud E, Abdelhamid D, Mohammed A, Almarhoon Z, Brase S, Youssif B, et al.
Pharmaceuticals (Basel) . 2025 Feb; 18(2). PMID: 40006087
New indole/1,2,4-triazole hybrids were synthesized and tested for antiproliferative activity against the NCI 60 cell line as tubulin polymerization inhibitors. All final compounds, - and - were evaluated at a...
2.
Design, synthesis, and antiproliferative activity of new indole/1,2,4-triazole/chalcone hybrids as EGFR and/or c-MET inhibitors
Mahmoud E, Abdelhamid D, Youssif B, Gomaa H, Hayallah A, Abdel-Aziz M
Arch Pharm (Weinheim) . 2024 Sep; 357(9):e2300562. PMID: 39219313
A novel group of indolyl-1,2,4-triazole-chalcone hybrids was designed, synthesized, and assessed for their anticancer activity. The synthesized compounds exhibited significant antiproliferative activity. Compounds 9a and 9e exhibited significant cancer inhibition...
3.
Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF: Design, Synthesis, and Antiproliferative Activity
Al-Wahaibi L, Hisham M, Abou-Zied H, Hassan H, Youssif B, Brase S, et al.
Pharmaceuticals (Basel) . 2023 Nov; 16(11). PMID: 38004388
A novel series of hybrid compounds comprising quinazolin-4-one and 3-cyanopyridin-2-one structures has been developed, with dual inhibitory actions on both EGFR and BRAF. These hybrid compounds were tested in vitro...
4.
Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAF Inhibitory Pathways
Al-Wahaibi L, Abou-Zied H, Hisham M, Beshr E, Youssif B, Brase S, et al.
Molecules . 2023 Sep; 28(18). PMID: 37764362
A series of novel 3-cyanopyridone/pyrazoline hybrids () exhibiting dual inhibition against EGFR and BRAF has been developed. The synthesized target compounds were tested in vitro against four cancer cell lines....
5.
Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis-Pyrazoline Derivatives as Dual EGFR/BRAF Inhibitors
Al-Wahaibi L, Abou-Zied H, Beshr E, Youssif B, Hayallah A, Abdel-Aziz M
Int J Mol Sci . 2023 May; 24(10). PMID: 37240450
Some new Bis-pyrazoline hybrids with dual EGFR and BRAF inhibitors have been developed. The target compounds were synthesized and tested in vitro against four cancer cell lines. Compounds , ,...
6.
Discovery of new cyanopyridine/chalcone hybrids as dual inhibitors of EGFR/BRAF with promising antiproliferative properties
Abou-Zied H, Beshr E, Gomaa H, Mostafa Y, Youssif B, Hayallah A, et al.
Arch Pharm (Weinheim) . 2022 Dec; 356(4):e2200464. PMID: 36526595
As dual EGFR and BRAF inhibitors, 2-(3-cyano-4,6-bis(aryl)-2-oxo-1,2-dihydropyridine-1-yl)-N-(4-cinnamoylphenyl) acetamide derivatives 8-20 were developed. Compounds 8, 12, and 13 showed strong antiproliferative activity when the target compounds were synthesized and tested in...
7.
Design, Synthesis, Molecular Modeling, and Anticancer Evaluation of New VEGFR-2 Inhibitors Based on the Indolin-2-One Scaffold
Abdelgawad M, Hayallah A, Bukhari S, Musa A, Elmowafy M, Abdel-Rahman H, et al.
Pharmaceuticals (Basel) . 2022 Nov; 15(11). PMID: 36422546
A new series of indoline-2-one derivatives was designed and synthesized based on the essential pharmacophoric features of VEGFR-2 inhibitors. Anti-proliferative activities were assessed for all derivatives against breast (MCF-7) and...
8.
Synthesis and molecular docking of new N4-piperazinyl ciprofloxacin hybrids as antimicrobial DNA gyrase inhibitors
Mohammed H, Ali D, Badr M, Habib A, Mahmoud A, Farhan S, et al.
Mol Divers . 2022 Sep; 27(4):1751-1765. PMID: 36152132
A series of N-4 piperazinyl ciprofloxacin derivatives as urea-tethered ciprofloxacin-chalcone hybrids 2a-j and thioacetyl-linked ciprofloxacin-pyrimidine hybrids 5a-i were synthesized. The target compounds were investigated for their antibacterial activity against S....
9.
Recent progress in biologically active indole hybrids: a mini review
Mahmoud E, Hayallah A, Kovacic S, Abdelhamid D, Abdel-Aziz M
Pharmacol Rep . 2022 May; 74(4):570-582. PMID: 35594012
The indole moiety is one of the most widespread heterocycles found in both natural products and biological systems. Indoles have important biological activities including anticancer, antioxidant, anti-inflammatory, antifungal, anticholinesterase, and...
10.
New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization
Mohammed H, Abd El-Hafeez A, Ebeid K, Mekkawy A, Abourehab M, Wafa E, et al.
J Enzyme Inhib Med Chem . 2022 May; 37(1):1346-1363. PMID: 35548854
A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones were synthesised as potential anticancer agents. Hybrids exhibited remarkable anti-proliferative activity against colon cancer cells. Compounds displayed ICs ranged from 2.53-8.67 µM, 8.67-62.47 µM,...