Ajai Tripathi
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Explore the profile of Ajai Tripathi including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
271
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Recent Articles
1.
Tripathi A, Rai N, Perles A, Jones C, Dutta R
bioRxiv
. 2023 Oct;
PMID: 37905110
Microglia are the resident immune cells of the central nervous system (CNS) and are important regulators of normal brain functions. In CNS demyelinating diseases like multiple sclerosis (MS), the functions...
2.
Kim D, Rai N, Burrows A, Kim S, Tripathi A, Weinberg S, et al.
J Immunol
. 2023 Jan;
210(6):721-731.
PMID: 36695771
Besides antiviral functions, type I IFN expresses potent anti-inflammatory properties and is being widely used to treat certain autoimmune conditions, such as multiple sclerosis. In a murine model of multiple...
3.
Rai N, Singh V, Li L, Willard B, Tripathi A, Dutta R
Front Neurol
. 2022 Jan;
12:779003.
PMID: 35002930
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system, where ongoing demyelination and remyelination failure are the major factors for progressive neurological disability. In...
4.
Baltan S, Sandau U, Brunet S, Bastian C, Tripathi A, Nguyen H, et al.
ASN Neuro
. 2021 Oct;
13:17590914211042220.
PMID: 34619990
We have previously shown that two anti-cancer drugs, CX-4945 and MS-275, protect and preserve white matter (WM) architecture and improve functional recovery in a model of WM ischemic injury. While...
5.
Tripathi A, Pandit I, Perles A, Zhou Y, Cheng F, Dutta R
Ann Clin Transl Neurol
. 2021 May;
8(6):1279-1291.
PMID: 33978322
Objective: Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS). Though MS was initially considered to be a white matter demyelinating disease, myelin...
6.
Sternbach S, West N, Singhal N, Clements R, Basu S, Tripathi A, et al.
PLoS One
. 2021 May;
16(5):e0250486.
PMID: 33975330
Research into the epigenome is of growing importance as a loss of epigenetic control has been implicated in the development of neurodegenerative diseases. Previous studies have implicated aberrant DNA and...
7.
Saraswat D, Shayya H, Polanco J, Tripathi A, Welliver R, Pol S, et al.
Nat Commun
. 2021 Mar;
12(1):1923.
PMID: 33772011
Chronic demyelination in the human CNS is characterized by an inhibitory microenvironment that impairs recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) leading to failed remyelination and axonal atrophy. By...
8.
Saraswat D, Welliver R, Ravichandar R, Tripathi A, Polanco J, Broome J, et al.
J Neurosci
. 2021 Jan;
41(10):2245-2263.
PMID: 33472827
The proinflammatory cytokine IFN-γ, which is chronically elevated in multiple sclerosis, induces pathologic quiescence in human oligodendrocyte progenitor cells (OPCs) via upregulation of the transcription factor PRRX1. In this study...
9.
Bhargava P, Smith M, Mische L, Harrington E, Fitzgerald K, Martin K, et al.
J Clin Invest
. 2020 Mar;
130(7):3467-3482.
PMID: 32182223
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are cholesterol metabolites that can signal through receptors on cells throughout the body, including in the CNS...
10.
Tripathi A, Volsko C, Garcia J, Agirre E, Allan K, Tesar P, et al.
Cell Rep
. 2019 Oct;
29(4):904-919.e9.
PMID: 31644912
Remyelination requires the generation of new oligodendrocytes (OLs), which are derived from oligodendrocyte progenitor cells (OPCs). Maturation of OPCs into OLs is a multi-step process. Here, we describe a microRNA...