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Aizhan Tastanova

Explore the profile of Aizhan Tastanova including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 14
Citations 141
Followers 0
Related Specialties
Oncology
Biology
Molecular Biology
Top 10 Co-Authors
Mitchell P Levesque
Christian Beisel
Zsolt Balazs
Michael Krauthammer
Patrick Turko
Phil F Cheng
Reinhard Dummer
Gaetana Restivo
Andreas Dzung
Federica Sella
Published In
J Mol Diagn
Commun Biol
J Biotechnol
Bioinformatics
Small Methods
Affiliations
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Recent Articles
1.
Human Dermal Microvascular Arterial and Venous Blood Endothelial Cells and Their Use in Bioengineered Dermo-Epidermal Skin Substitutes
Rutsche D, Nanni M, Cheng P, Caflisch N, Tastanova A, Jenni C, et al.
Small Methods . 2025 Jan; e2401588. PMID: 39871784
The bioengineering of vascular networks is pivotal to create complex tissues and organs for regenerative medicine applications. However, bioengineered tissues comprising an arterial and venous plexus alongside a lymphatic capillary...
2.
A targetable type III immune response with increase of IL-17A expressing CD4 T cells is associated with immunotherapy-induced toxicity in melanoma
Dimitriou F, Cheng P, Saltari A, Schaper-Gerhardt K, Staeger R, Haunerdinger V, et al.
Nat Cancer . 2024 Aug; 5(9):1390-1408. PMID: 39210005
Immune checkpoint inhibitors are standard-of-care for the treatment of advanced melanoma, but their use is limited by immune-related adverse events. Proteomic analyses and multiplex cytokine and chemokine assays from serum...
3.
COL10A1 expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma
Esposito M, Yerly L, Shukla P, Hermes V, Sella F, Balazs Z, et al.
Br J Dermatol . 2024 Jun; 191(5):775-790. PMID: 38916477
Background: Basal cell carcinoma (BCC) is the most frequently diagnosed skin cancer and the most common malignancy in humans. Different morphological subtypes of BCC are associated with a low or...
4.
Dynamic thresholding and tissue dissociation optimization for CITE-seq identifies differential surface protein abundance in metastatic melanoma
Lischetti U, Tastanova A, Singer F, Grob L, Carrara M, Cheng P, et al.
Commun Biol . 2023 Aug; 6(1):830. PMID: 37563418
Multi-omics profiling by CITE-seq bridges the RNA-protein gap in single-cell analysis but has been largely applied to liquid biopsies. Applying CITE-seq to clinically relevant solid biopsies to characterize healthy tissue...
5.
gExcite: a start-to-end framework for single-cell gene expression, hashing, and antibody analysis
Grob L, Bertolini A, Carrara M, Lischetti U, Tastanova A, Beisel C, et al.
Bioinformatics . 2023 May; 39(5). PMID: 37220897
Summary: Recently, CITE-seq emerged as a multimodal single-cell technology capturing gene expression and surface protein information from the same single cells, which allows unprecedented insights into disease mechanisms and heterogeneity,...
6.
ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Eichhoff O, Stoffel C, Kasler J, Briker L, Turko P, Karsai G, et al.
Cancer Res . 2023 Mar; 83(7):1128-1146. PMID: 36946761
Significance: Metabolic reprogramming in drug-resistant NRAS-mutated melanoma cells confers sensitivity to ROS induction, which suppresses tumor growth and metastasis in combination with MAPK pathway inhibitors.
7.
Guadecitabine increases response to combined anti-CTLA-4 and anti-PD-1 treatment in mouse melanoma in vivo by controlling T-cells, myeloid derived suppressor and NK cells
Amaro A, Reggiani F, Fenoglio D, Gangemi R, Tosi A, Parodi A, et al.
J Exp Clin Cancer Res . 2023 Mar; 42(1):67. PMID: 36934257
Background: The combination of Programmed Cell Death 1 (PD-1) and Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) blockade has dramatically improved the overall survival rate for malignant melanoma. Immune checkpoint blockers (ICBs)...
8.
Live slow-frozen human tumor tissues viable for 2D, 3D, ex vivo cultures and single-cell RNAseq
Restivo G, Tastanova A, Balazs Z, Panebianco F, Diepenbruck M, Ercan C, et al.
Commun Biol . 2022 Oct; 5(1):1144. PMID: 36307545
Biobanking of surplus human healthy and disease-derived tissues is essential for diagnostics and translational research. An enormous amount of formalin-fixed and paraffin-embedded (FFPE), Tissue-Tek OCT embedded or snap-frozen tissues are...
9.
An Optimized Tissue Dissociation Protocol for Single-Cell RNA Sequencing Analysis of Fresh and Cultured Human Skin Biopsies
Burja B, Paul D, Tastanova A, Edalat S, Gerber R, Houtman M, et al.
Front Cell Dev Biol . 2022 May; 10:872688. PMID: 35573685
We present an optimized dissociation protocol for preparing high-quality skin cell suspensions for in-depth single-cell RNA-sequencing (scRNA-seq) analysis of fresh and cultured human skin. Our protocol enabled the isolation of...
10.
Collection and preprocessing of fine needle aspirate patient samples for single cell profiling and data analysis
Tastanova A, Ramelyte E, Balazs Z, Menzel U, Beisel C, Krauthammer M, et al.
STAR Protoc . 2021 Jun; 2(2):100581. PMID: 34151301
High cell viability and recovered cell concentration are typical quality control requirements for single-cell processing and quality data. This protocol describes procedures for sampling, live-cell biobanking, preprocessing for single-cell RNA...