Ahmad Wardak
Overview
Explore the profile of Ahmad Wardak including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
242
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0
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Recent Articles
1.
Sethi A, Horne C, Fitzgibbon C, Wilde K, Davies K, Garnish S, et al.
Cell Death Differ
. 2022 Mar;
29(9):1804-1815.
PMID: 35264780
Necroptosis is a lytic programmed cell death pathway with origins in innate immunity that is frequently dysregulated in inflammatory diseases. The terminal effector of the pathway, MLKL, is licensed to...
2.
Jin R, He S, Black K, Clarke O, Wu D, Bolla J, et al.
Nat Commun
. 2022 Jan;
13(1):490.
PMID: 35079013
Ion currents through potassium channels are gated. Constriction of the ion conduction pathway at the inner helix bundle, the textbook gate of Kir potassium channels, has been shown to be...
3.
van Delft M, Chappaz S, Khakham Y, Bui C, Debrincat M, Lowes K, et al.
Nat Chem Biol
. 2019 Oct;
15(11):1057-1066.
PMID: 31591564
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease...
4.
Robin A, Iyer S, Birkinshaw R, Sandow J, Wardak A, Luo C, et al.
Structure
. 2018 Aug;
26(10):1346-1359.e5.
PMID: 30122452
BAX and BAK are essential mediators of intrinsic apoptosis that permeabilize the mitochondrial outer membrane. BAX activation requires its translocation from cytosol to mitochondria where conformational changes cause its oligomerization....
5.
Bandala-Sanchez E, Bediaga N, Goddard-Borger E, Ngui K, Naselli G, Stone N, et al.
Proc Natl Acad Sci U S A
. 2018 Jul;
115(30):7783-7788.
PMID: 29997173
CD52, a glycophosphatidylinositol (GPI)-anchored glycoprotein, is released in a soluble form following T cell activation and binds to the Siglec (sialic acid-binding Ig-like lectin)-10 receptor on T cells to suppress...
6.
Petrie E, Sandow J, Jacobsen A, Smith B, Griffin M, Lucet I, et al.
Nat Commun
. 2018 Jun;
9(1):2422.
PMID: 29930286
Necroptotic cell death is mediated by the most terminal known effector of the pathway, MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by the upstream kinase, RIPK3,...
7.
Brouwer J, Lan P, Cowan A, Bernardini J, Birkinshaw R, van Delft M, et al.
Mol Cell
. 2017 Nov;
68(4):659-672.e9.
PMID: 29149594
Certain BH3-only proteins transiently bind and activate Bak and Bax, initiating their oligomerization and the permeabilization of the mitochondrial outer membrane, a pivotal step in the mitochondrial pathway to apoptosis....