Adrien Guillot
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Explore the profile of Adrien Guillot including associated specialties, affiliations and a list of published articles.
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52
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1196
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Recent Articles
1.
Sugimoto A, Saito Y, Wang G, Sun Q, Yin C, Lee K, et al.
Nature
. 2025 Mar;
PMID: 40074890
Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood. Here we demonstrate that genetic depletion...
2.
Volkert I, Grube J, Woitok M, Mohamed M, Edlund K, Duda J, et al.
Hepatology
. 2025 Feb;
PMID: 40009601
Background And Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is associated with c-Jun N-terminal kinases (JNK) activation across various cell types, but its hepatocyte-specific function in steatotic liver disease remains unclear. Our...
3.
Laschtowitz A, Lindberg E, Liebhoff A, Liebig L, Casar C, Steinmann S, et al.
JHEP Rep
. 2025 Feb;
7(3):101267.
PMID: 39996122
Background & Aims: Primary sclerosing cholangitis (PSC) is a chronic heterogenous cholangiopathy with unknown etiology where chronic inflammation of the bile ducts leads to multifocal biliary strictures and biliary fibrosis...
4.
Guillot A, Tacke F
eGastroenterology
. 2025 Feb;
1(1):e000003.
PMID: 39944246
The structural and cellular organisation of the liver has unique features that define it as both a metabolic and an immunological organ. Noteworthy, liver resident macrophages, named Kupffer cells, represent...
5.
Schneider K, Cao F, Huang H, Chen L, Chen Y, Gong R, et al.
Aliment Pharmacol Ther
. 2025 Feb;
PMID: 39935287
Background: The recent consensus statement redefined steatotic liver diseases. Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction and alcohol-related liver disease (MetALD) now represent distinct disease entities. However, biomarkers...
6.
David B, Atif J, Vargas E Silva Castanheira F, Yasmin T, Guillot A, Ait Ahmed Y, et al.
Sci Immunol
. 2024 Nov;
9(101):eadq9704.
PMID: 39485859
In adults, liver-resident macrophages, or Kupffer cells (KCs), reside in the sinusoids and sterilize circulating blood by capturing rapidly flowing microbes. We developed quantitative intravital imaging of 1-day-old mice combined...
7.
Hagele M, Eschrich J, Ruff L, Alber M, Schallenberg S, Guillot A, et al.
Sci Rep
. 2024 Oct;
14(1):24988.
PMID: 39443575
In this paper we present a deep learning segmentation approach to classify and quantify the two most prevalent primary liver cancers - hepatocellular carcinoma and intrahepatic cholangiocarcinoma - from hematoxylin...
8.
Rezvani M, Lewis K, Quach S, Iwasawa K, Weihs J, Reza H, et al.
bioRxiv
. 2024 Oct;
PMID: 39416072
The fetal liver is a hematopoietic organ, hosting a diverse and evolving progenitor population. While human liver organoids derived from pluripotent stem cells (PSCs) mimic aspects of embryonic and fetal...
9.
Chen S, Zeng Q, Cai X, Xue J, Yin G, Song P, et al.
Int J Biol Sci
. 2024 Sep;
20(11):4438-4457.
PMID: 39247824
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic, progressive liver disease that encompasses a spectrum of steatosis, steatohepatitis (or MASH), and fibrosis. Evidence suggests that dietary restriction (DR) and...
10.
Guillot A, Tacke F
Hepatol Commun
. 2024 Jul;
8(7).
PMID: 38967563
The liver is a vital organ that continuously adapts to a wide and dynamic diversity of self-antigens and xenobiotics. This involves the active contribution of immune cells, particularly by the...