Moritz Peiseler
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Explore the profile of Moritz Peiseler including associated specialties, affiliations and a list of published articles.
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36
Citations
1317
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Recent Articles
1.
Sugimoto A, Saito Y, Wang G, Sun Q, Yin C, Lee K, et al.
Nature
. 2025 Mar;
PMID: 40074890
Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood. Here we demonstrate that genetic depletion...
2.
David B, Atif J, Vargas E Silva Castanheira F, Yasmin T, Guillot A, Ait Ahmed Y, et al.
Sci Immunol
. 2024 Nov;
9(101):eadq9704.
PMID: 39485859
In adults, liver-resident macrophages, or Kupffer cells (KCs), reside in the sinusoids and sterilize circulating blood by capturing rapidly flowing microbes. We developed quantitative intravital imaging of 1-day-old mice combined...
3.
Wang Y, Heymann F, Peiseler M
Gut
. 2024 May;
73(8):1364-1375.
PMID: 38777574
Inflammation is a critical component of most acute and chronic liver diseases. The liver is a unique immunological organ with a dense vascular network, leading to intense crosstalk between tissue-resident...
4.
Niemietz P, Peiseler M, Kohlhepp M, Horn P, Matchett K, Wang Y, et al.
Hepatology
. 2024 Jan;
80(5):1104-1119.
PMID: 38231043
Background And Aims: Acute liver failure (ALF) is a rare but life-threatening condition, and DILI, particularly acetaminophen toxicity, is the leading cause of ALF. Innate immune mechanisms further perpetuate liver...
5.
Peiseler M, David B, Zindel J, Surewaard B, Lee W, Heymann F, et al.
Science
. 2023 Sep;
381(6662):eabq5202.
PMID: 37676943
Kupffer cells (KCs) are localized in liver sinusoids but extend pseudopods to parenchymal cells to maintain their identity and serve as the body's central bacterial filter. Liver cirrhosis drastically alters...
6.
7.
Arino S, Aguilar-Bravo B, Coll M, Lee W, Peiseler M, Cantallops-Vila P, et al.
J Hepatol
. 2023 Jun;
79(4):1025-1036.
PMID: 37348790
Background & Aims: Ductular reaction expansion is associated with poor prognosis in patients with advanced liver disease. However, the mechanisms promoting biliary cell proliferation are largely unknown. Here, we identify...
8.
Heymann F, Mossanen J, Peiseler M, Niemietz P, David B, Krenkel O, et al.
Hepatol Commun
. 2023 Mar;
7(4).
PMID: 36972392
Background: Acute liver failure (ALF) is characterized by rapid clinical deterioration and high mortality. Acetaminophen (APAP or paracetamol) overdose is a leading cause of ALF, resulting in hepatocellular necrosis with...
9.
Guillot A, Winkler M, Afonso M, Aggarwal A, Lopez D, Berger H, et al.
Hepatology
. 2023 Jan;
78(1):150-166.
PMID: 36630995
Background And Aims: The progression of chronic liver diseases towards liver cirrhosis is accompanied by drastic tissue changes. This study combines elaborate transcriptomic and histological methods aiming at spatially resolving...
10.
Peiseler M, Schwabe R, Hampe J, Kubes P, Heikenwalder M, Tacke F
J Hepatol
. 2022 Jun;
77(4):1136-1160.
PMID: 35750137
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular carcinoma (HCC). NAFLD is a...