Adrie H Westphal
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Explore the profile of Adrie H Westphal including associated specialties, affiliations and a list of published articles.
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77
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1483
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Recent Articles
1.
Pacesa M, Nickel L, Schellhaas C, Schmidt J, Pyatova E, Kissling L, et al.
bioRxiv
. 2024 Dec;
PMID: 39677777
Protein-protein interactions (PPIs) are at the core of all key biological processes. However, the complexity of the structural features that determine PPIs makes their design challenging. We present BindCraft, an...
2.
Finocchio G, Koopal B, Potocnik A, Heijstek C, Westphal A, Jinek M, et al.
Nucleic Acids Res
. 2024 Jan;
52(4):2012-2029.
PMID: 38224450
In both prokaryotic and eukaryotic innate immune systems, TIR domains function as NADases that degrade the key metabolite NAD+ or generate signaling molecules. Catalytic activation of TIR domains requires oligomerization,...
3.
Charged Polypeptide Tail Boosts the Salt Resistance of Enzyme-Containing Complex Coacervate Micelles
Kembaren R, Westphal A, Kamperman M, Kleijn J, Borst J
Biomacromolecules
. 2022 Jan;
23(3):1195-1204.
PMID: 35042326
Encapsulation of proteins can have advantages for their protection, stability, and delivery purposes. One of the options to encapsulate proteins is to incorporate them in complex coacervate core micelles (C3Ms)....
4.
van Oosten L, Altenburg J, Fougeroux C, Geertsema C, van den End F, Evers W, et al.
mBio
. 2021 Oct;
12(5):e0181321.
PMID: 34634927
Vaccines pave the way out of the SARS-CoV-2 pandemic. Besides mRNA and adenoviral vector vaccines, effective protein-based vaccines are needed for immunization against current and emerging variants. We have developed...
5.
Nederveen-Schippers L, Pathak P, Keizer-Gunnink I, Westphal A, van Haastert P, Borst J, et al.
Int J Mol Sci
. 2021 Jul;
22(14).
PMID: 34298920
Protein dimerization plays a crucial role in the regulation of numerous biological processes. However, detecting protein dimers in a cellular environment is still a challenge. Here we present a methodology...
6.
Westphal A, Tischler D, van Berkel W
Arch Biochem Biophys
. 2021 Mar;
702:108820.
PMID: 33684360
4-Hydroxybenzoate 3-hydroxylase (PHBH) is the most extensively studied group A flavoprotein monooxygenase (FPMO). PHBH is almost exclusively found in prokaryotes, where its induction, usually as a consequence of lignin degradation,...
7.
Paul C, Eggerichs D, Westphal A, Tischler D, van Berkel W
Biotechnol Adv
. 2021 Feb;
51:107712.
PMID: 33588053
Flavoprotein monooxygenases (FPMOs) are single- or two-component enzymes that catalyze a diverse set of chemo-, regio- and enantioselective oxyfunctionalization reactions. In this review, we describe how FPMOs have evolved from...
8.
Kembaren R, Fokkink R, Westphal A, Kamperman M, Kleijn J, Borst J
Langmuir
. 2020 Jun;
36(29):8494-8502.
PMID: 32598154
Encapsulation of charged proteins into complex coacervate core micelles (C3Ms) can be accomplished by mixing them with oppositely charged diblock copolymers. However, these micelles tend to disintegrate at high ionic...
9.
Bastiaan-Net S, Pina-Perez M, Dekkers B, Westphal A, America A, Ariens R, et al.
Protein Sci
. 2020 Mar;
29(7):1581-1595.
PMID: 32219913
Proteins from cashew nut can elicit mild to severe allergic reactions. Three allergenic proteins have already been identified, and it is expected that additional allergens are present in cashew nut....
10.
Luo Q, Sewalt E, Borst J, Westphal A, Boom R, Janssen A
Food Res Int
. 2019 Apr;
120:449-455.
PMID: 31000261
During gastric digestion, hydrolysis of proteins by pepsin contributes largely to the breakdown of protein-rich food. We hypothesized that the effect of pepsin is limited by its diffusivity, which is...