Adriana Ortiz-Lopez
Overview
Explore the profile of Adriana Ortiz-Lopez including associated specialties, affiliations and a list of published articles.
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22
Citations
1989
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Recent Articles
1.
Zarin P, Shwartz Y, Ortiz-Lopez A, Hanna B, Sassone-Corsi M, Hsu Y, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(14):e2221255120.
PMID: 36972453
Izumo1R is a pseudo-folate receptor with an essential role in mediating tight oocyte/spermatozoa contacts during fertilization. Intriguingly, it is also expressed in CD4 T lymphocytes, in particular Treg cells under...
2.
Sassone-Corsi M, Azriel S, Simon A, Ramanan D, Ortiz-Lopez A, Chen F, et al.
Proc Natl Acad Sci U S A
. 2022 Oct;
119(41):e2209624119.
PMID: 36201539
T cells that express the transcription factor RORγ, regulatory (Treg), or conventional (Th17) are strongly influenced by intestinal symbionts. In a genetic approach to identify mechanisms underlying this influence, we...
3.
Magnuson A, Kiner E, Ergun A, Park J, Asinovski N, Ortiz-Lopez A, et al.
Proc Natl Acad Sci U S A
. 2018 Oct;
115(45):E10672-E10681.
PMID: 30348759
FoxP3 T regulatory (Treg) cells are central elements of immunologic tolerance. They are abundant in many tumors, where they restrict potentially favorable antitumor responses. We used a three-pronged strategy to...
4.
Geva-Zatorsky N, Sefik E, Kua L, Pasman L, Tan T, Ortiz-Lopez A, et al.
Cell
. 2017 Feb;
168(5):928-943.e11.
PMID: 28215708
Within the human gut reside diverse microbes coexisting with the host in a mutually advantageous relationship. Evidence has revealed the pivotal role of the gut microbiota in shaping the immune...
5.
Tan T, Sefik E, Geva-Zatorsky N, Kua L, Naskar D, Teng F, et al.
Proc Natl Acad Sci U S A
. 2016 Dec;
113(50):E8141-E8150.
PMID: 27911839
Th17 cells accrue in the intestine in response to particular microbes. In rodents, segmented filamentous bacteria (SFB) induce intestinal Th17 cells, but analogously functioning microbes in humans remain undefined. Here,...
6.
Moodley D, Yoshida H, Mostafavi S, Asinovski N, Ortiz-Lopez A, Symanowicz P, et al.
Proc Natl Acad Sci U S A
. 2016 Aug;
113(35):9852-7.
PMID: 27516546
Small-molecule inhibitors of the Janus kinase family (JAKis) are clinically efficacious in multiple autoimmune diseases, albeit with increased risk of certain infections. Their precise mechanism of action is unclear, with...
7.
Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, Manson McGuire A, et al.
Science
. 2015 Aug;
349(6251):993-7.
PMID: 26272906
T regulatory cells that express the transcription factor Foxp3 (Foxp3(+) T(regs)) promote tissue homeostasis in several settings. We now report that symbiotic members of the human gut microbiota induce a...
8.
Ericson J, Duffau P, Yasuda K, Ortiz-Lopez A, Rothamel K, Rifkin I, et al.
PLoS One
. 2014 Oct;
9(10):e108553.
PMID: 25279834
As part of the Immunological Genome Project (ImmGen), gene expression was determined in unstimulated (circulating) mouse neutrophils and three populations of neutrophils activated in vivo, with comparison among these populations...
9.
Mostafavi S, Ortiz-Lopez A, Bogue M, Hattori K, Pop C, Koller D, et al.
J Immunol
. 2014 Oct;
193(9):4485-96.
PMID: 25267973
To determine the breadth and underpinning of changes in immunocyte gene expression due to genetic variation in mice, we performed, as part of the Immunological Genome Project, gene expression profiling...
10.
Gutierrez D, Fu W, Schonefeldt S, Feyerabend T, Ortiz-Lopez A, Lampi Y, et al.
Diabetes
. 2014 Jun;
63(11):3827-34.
PMID: 24917576
Mast cells have been invoked as important players in immune responses associated with autoimmune diseases. Based on in vitro studies, or in vivo through the use of Kit mutant mice,...