Adrian M Jubb
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Explore the profile of Adrian M Jubb including associated specialties, affiliations and a list of published articles.
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44
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2410
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Recent Articles
1.
Heilbron K, Mozaffari S, Vacic V, Yue P, Wang W, Shi J, et al.
J Pathol
. 2021 Mar;
254(4):418-429.
PMID: 33748968
Human genetics plays an increasingly important role in drug development and population health. Here we review the history of human genetics in the context of accelerating the discovery of therapies,...
2.
McKinnell J, Dwyer J, Talbot G, Connolly L, Friedland I, Smith A, et al.
N Engl J Med
. 2019 Feb;
380(8):791-793.
PMID: 30786196
No abstract available.
3.
Ong C, Gierke S, Pitt C, Sagolla M, Cheng C, Zhou W, et al.
Breast Cancer Res
. 2015 Apr;
17:59.
PMID: 25902869
Introduction: Breast cancer, the most common cause of cancer-related deaths worldwide among women, is a molecularly and clinically heterogeneous disease. Extensive genetic and epigenetic profiling of breast tumors has recently...
4.
Fuji R, Flagella M, Baca M, Baptista M, Brodbeck J, Chan B, et al.
Sci Transl Med
. 2015 Feb;
7(273):273ra15.
PMID: 25653221
Inhibition of the kinase activity of leucine-rich repeat kinase 2 (LRRK2) is under investigation as a possible treatment for Parkinson's disease. However, there is no clinical validation as yet, and...
5.
Zhou W, Jubb A, Lyle K, Xiao Q, Ong C, Desai R, et al.
J Pathol
. 2014 Jul;
234(4):502-13.
PMID: 25074413
Pancreatic adenocarcinoma (PDAC) is a major unmet medical need and a deeper understanding of molecular drivers is needed to advance therapeutic options for patients. We report here that p21-activated kinase...
6.
Kallop D, Meilandt W, Gogineni A, Easley-Neal C, Wu T, Jubb A, et al.
J Neurosci
. 2014 May;
34(19):6425-37.
PMID: 24806669
Recent studies implicate death receptor 6 (DR6) in an amyloid precursor protein (APP)-dependent pathway regulating developmental axon pruning, and in a pruning pathway operating during plastic rearrangements in adult brain....
7.
Enquist I, Good Z, Jubb A, Fuh G, Wang X, Junttila M, et al.
Nat Commun
. 2014 Mar;
5:3530.
PMID: 24667486
Deciphering metastatic routes is critically important as metastasis is a primary cause of cancer mortality. In colorectal cancer (CRC), it is unknown whether liver metastases derive from cancer cells that...
8.
MacFie T, Poulsom R, Parker A, Warnes G, Boitsova T, Nijhuis A, et al.
Inflamm Bowel Dis
. 2014 Feb;
20(3):514-24.
PMID: 24492313
Background: NADPH oxidase-derived reactive oxygen species, such as H2O2, are part of the intestinal innate immune system but may drive carcinogenesis through DNA damage. We sought to identify the predominant...
9.
Pozniak C, Sengupta Ghosh A, Gogineni A, Hanson J, Lee S, Larson J, et al.
J Exp Med
. 2013 Oct;
210(12):2553-67.
PMID: 24166713
Excessive glutamate signaling is thought to underlie neurodegeneration in multiple contexts, yet the pro-degenerative signaling pathways downstream of glutamate receptor activation are not well defined. We show that dual leucine...
10.
Jubb A, Koeppen H, Reis-Filho J
J Pathol
. 2013 Oct;
232(2):99-102.
PMID: 24122335
The rapid pace of drug discovery and drug development in oncology, immunology and ophthalmology brings new challenges; the efficient and effective development of new targeted drugs will require more detailed...