Adrian J Thrasher
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Explore the profile of Adrian J Thrasher including associated specialties, affiliations and a list of published articles.
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333
Citations
14515
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Recent Articles
21.
Senthil S, Thrasher A, Gilmour K, Wright T, Wynn R
J Clin Immunol
. 2022 Sep;
43(1):82-84.
PMID: 36169901
No abstract available.
22.
Daza-Cajigal V, Albuquerque A, Young D, Ciancanelli M, Moulding D, Angulo I, et al.
Front Immunol
. 2022 Sep;
13:888427.
PMID: 36159783
Purpose: Janus kinase-1 (JAK1) tyrosine kinase mediates signaling from multiple cytokine receptors, including interferon alpha/beta and gamma (IFN-α/β and IFN-γ), which are important for viral and mycobacterial protection respectively. We...
23.
Rae W, Sowerby J, Verhoeven D, Youssef M, Kotagiri P, Savinykh N, et al.
Sci Immunol
. 2022 Aug;
7(74):eabn3800.
PMID: 35960817
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a central regulator of immunity. TRAF3 is often somatically mutated in B cell malignancies, but its role in human immunity is not...
24.
Panchal N, Houghton B, Vassalou E, Thrasher A, Booth C
J Allergy Clin Immunol
. 2022 Jul;
150(6):1507-1516.e7.
PMID: 35839843
Background: X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency arising from SH2D1A mutations leading to loss of SLAM-associated protein (SAP). SAP is an intracellular adaptor protein that binds to SLAM...
25.
Houghton B, Panchal N, Haas S, Chmielewski K, Hildenbeutel M, Whittaker T, et al.
Front Genome Ed
. 2022 Jun;
4:828489.
PMID: 35677600
X-linked lymphoproliferative disease is a rare inherited immune disorder, caused by mutations or deletions in the gene that encodes an intracellular adapter protein SAP (Slam-associated protein). SAP is essential for...
26.
Hong Y, Casimir M, Houghton B, Zhang F, Jensen B, Omoyinmi E, et al.
Front Immunol
. 2022 May;
13:852830.
PMID: 35529868
Deficiency of adenosine deaminase type 2 (DADA2) is an autosomal recessive disease caused by bi-allelic loss-of-function mutations in . Treatment with anti-TNF is effective for the autoinflammatory and vasculitic components...
27.
Westhaus A, Cabanes-Creus M, Jonker T, Sallard E, Navarro R, Zhu E, et al.
Hum Gene Ther
. 2022 Mar;
33(11-12):664-682.
PMID: 35297686
The power of adeno-associated viral (AAV)-directed evolution for identifying novel vector variants with improved properties is well established, as evidenced by numerous publications reporting novel AAV variants. However, most capsid...
28.
Descatoire M, Fritzen R, Rotman S, Kuntzelman G, Leber X, Droz-Georget S, et al.
Cell Rep
. 2022 Mar;
38(10):110474.
PMID: 35263577
A main feature of Wiskott-Aldrich syndrome (WAS) is increased susceptibility to autoimmunity. A key contribution of B cells to development of these complications has been demonstrated through studies of samples...
29.
Cabanes-Creus M, Navarro R, Zhu E, Baltazar G, Liao S, Drouyer M, et al.
Mol Ther Methods Clin Dev
. 2022 Jan;
24:88-101.
PMID: 34977275
Recent clinical successes have intensified interest in using adeno-associated virus (AAV) vectors for therapeutic gene delivery. The liver is a key clinical target, given its critical physiological functions and involvement...
30.
Locatelli F, Thompson A, Kwiatkowski J, Porter J, Thrasher A, Hongeng S, et al.
N Engl J Med
. 2021 Dec;
386(5):415-427.
PMID: 34891223
Background: Betibeglogene autotemcel (beti-cel) gene therapy for transfusion-dependent β-thalassemia contains autologous CD34+ hematopoietic stem cells and progenitor cells transduced with the BB305 lentiviral vector encoding the β-globin (β) gene. Methods:...