Adrian J Lambert
Overview
Explore the profile of Adrian J Lambert including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
1473
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Recent Articles
1.
Jacobson J, Lambert A, Portero-Otin M, Pamplona R, Magwere T, Miwa S, et al.
Aging Cell
. 2010 Apr;
9(4):466-477.
PMID: 20367621
Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases with...
2.
Lambert A, Buckingham J, Boysen H, Brand M
Aging Cell
. 2009 Dec;
9(1):78-91.
PMID: 19968628
Across a range of vertebrate species, it is known that there is a negative association between maximum lifespan and mitochondrial hydrogen peroxide production. In this report, we investigate the underlying...
3.
Lambert A, Brand M
Methods Mol Biol
. 2009 Jun;
554:165-81.
PMID: 19513674
Oxidative damage to cellular macromolecules is believed to underlie the development of many pathological states and aging. The agents responsible for this damage are generally thought to be reactive oxygen...
4.
Lambert A, Buckingham J, Brand M
FEBS Lett
. 2008 Apr;
582(12):1711-4.
PMID: 18442479
The relationship between the rate of superoxide production by complex I and NAD(P)H redox state was investigated in rat skeletal muscle mitochondria. A high rate of superoxide production was observed...
5.
Lambert A, Buckingham J, Boysen H, Brand M
Biochim Biophys Acta
. 2008 Apr;
1777(5):397-403.
PMID: 18395512
We investigated the effects of diphenyleneiodonium (DPI) on superoxide production by complex I in mitochondria isolated from rat skeletal muscle. Superoxide production was measured indirectly as hydrogen peroxide production. In...
6.
Lambert A, Brand M
Aging Cell
. 2007 Jul;
6(4):417-20.
PMID: 17635416
This review focuses on some of the 'hot topics' that fall under the general heading 'mitochondria and aging'. For each selected topic, we highlight recent publications that have either addressed...
7.
Lambert A, Boysen H, Buckingham J, Yang T, Podlutsky A, Austad S, et al.
Aging Cell
. 2007 Jun;
6(5):607-18.
PMID: 17596208
An inverse correlation between free radical production by isolated mitochondria and longevity in homeotherms has been reported, but previous comparative studies ignored possible confounding effects of body mass and phylogeny....
8.
Lambert A, Merry B
J Gerontol A Biol Sci Med Sci
. 2005 Apr;
60(2):175-80.
PMID: 15814858
To investigate the hypothesis that caloric restriction alters mitochondrial function in situ, intact hepatocytes were isolated from fully fed and calorie-restricted (55% of control food intake, 4 months duration) male...
9.
Brand M, Buckingham J, Esteves T, Green K, Lambert A, Miwa S, et al.
Biochem Soc Symp
. 2005 Mar;
(71):203-13.
PMID: 15777023
Mitochondria are a major source of superoxide, formed by the one-electron reduction of oxygen during electron transport. Superoxide initiates oxidative damage to phospholipids, proteins and nucleic acids. This damage may...
10.
Lambert A, Portero-Otin M, Pamplona R, Merry B
Mech Ageing Dev
. 2004 Sep;
125(8):529-38.
PMID: 15336910
To gain insight into the anti-ageing mechanisms of caloric restriction (CR), liver mitochondria were isolated from male Brown-Norway rats of different ages (fully fed control and CR) and various specific...