Darren A Talbot
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Explore the profile of Darren A Talbot including associated specialties, affiliations and a list of published articles.
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10
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472
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Recent Articles
1.
Ammann E, OBrien E, Milentijevic D, Kharat A, Talbot D, Canovatchel W, et al.
Heliyon
. 2023 Feb;
9(2):e13258.
PMID: 36846680
Background: Per treatment guidelines, resistant hypertension is defined as uncontrolled blood pressure (BP) while taking 3 concomitant antihypertensives (AHTs) or controlled BP while taking ≥4 AHTs. Characteristics, AHT therapy use,...
2.
Chalet F, Briasoulis O, Manalastas E, Talbot D, Thompson J, Loch Macdonald R
Neurol Ther
. 2023 Jan;
12(2):371-390.
PMID: 36609962
Introduction: Angiographic vasospasm (VSP), the narrowing of intracranial arteries, is a complication of aneurysmal subarachnoid hemorrhage (aSAH) and often results in delayed cerebral ischemia (DCI) and cerebral infarction. The objective...
3.
Thompson J, Chalet F, Manalastas E, Hawkins N, Sarri G, Talbot D
Neurol Ther
. 2022 Apr;
11(2):597-620.
PMID: 35441974
Introduction: Cerebral vasospasm (VSP) is the leading risk factor of neurological deterioration (i.e., delayed cerebral ischemia [DCI] and cerebral infarction) after aneurysmal subarachnoid hemorrhage (aSAH) and a cause of morbidity...
4.
Talbot D, Brand M
Biochim Biophys Acta
. 2005 Aug;
1709(2):150-6.
PMID: 16084485
Mitochondrial uncoupling proteins only catalyse proton transport when they are activated. Activators include superoxide and reactive alkenals, suggesting new physiological functions for UCP2 and UCP3: their activation by superoxide when...
5.
Brand M, Buckingham J, Esteves T, Green K, Lambert A, Miwa S, et al.
Biochem Soc Symp
. 2005 Mar;
(71):203-13.
PMID: 15777023
Mitochondria are a major source of superoxide, formed by the one-electron reduction of oxygen during electron transport. Superoxide initiates oxidative damage to phospholipids, proteins and nucleic acids. This damage may...
6.
Speakman J, Talbot D, Selman C, Snart S, McLaren J, Redman P, et al.
Aging Cell
. 2004 May;
3(3):87-95.
PMID: 15153176
Two theories of how energy metabolism should be associated with longevity, both mediated via free-radical production, make completely contrary predictions. The 'rate of living-free-radical theory' (Pearl, 1928; Harman, 1956; Sohal,...
7.
Talbot D, Duchamp C, Rey B, Hanuise N, Rouanet J, Sibille B, et al.
J Physiol
. 2004 May;
558(Pt 1):123-35.
PMID: 15146050
Juvenile king penguins develop adaptive thermogenesis after repeated immersion in cold water. However, the mechanisms of such metabolic adaptation in birds are unknown, as they lack brown adipose tissue and...
8.
Talbot D, Lambert A, Brand M
FEBS Lett
. 2004 Jan;
556(1-3):111-5.
PMID: 14706836
Superoxide generated using exogenous xanthine oxidase indirectly activates an uncoupling protein (UCP)-mediated proton conductance of the mitochondrial inner membrane. We investigated whether endogenous mitochondrial superoxide production could also activate proton...
9.
Talbot D, Hanuise N, Rey B, Rouanet J, Duchamp C, Brand M
Biochem Biophys Res Commun
. 2003 Dec;
312(4):983-8.
PMID: 14651968
We present the partial nucleotide sequence of the avian uncoupling protein (avUCP) gene from king penguin (Aptenodytes patagonicus), showing that the protein is 88-92% identical to chicken (Gallus gallus), turkey...
10.
Echtay K, Murphy M, Smith R, Talbot D, Brand M
J Biol Chem
. 2002 Oct;
277(49):47129-35.
PMID: 12372827
Superoxide activates nucleotide-sensitive mitochondrial proton transport through the uncoupling proteins UCP1, UCP2, and UCP3 (Echtay, K. S., et al. (2002) Nature 415, 1482-1486). Two possible mechanisms were proposed: direct activation...