Manuel Portero-Otin
Overview
Explore the profile of Manuel Portero-Otin including associated specialties, affiliations and a list of published articles.
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179
Citations
4859
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Recent Articles
1.
Fontdevila L, Povedano M, Dominguez R, Boada J, Serrano J, Pamplona R, et al.
Sci Rep
. 2024 Oct;
14(1):23497.
PMID: 39379597
This study aimed to assess differences in the enteral microbiome of relatively recent-onset amyotrophic lateral sclerosis (ALS) patients (< 6-15 months since symptom onset) compared to healthy individuals, focusing on...
2.
Torres P, Rico-Rios S, Ceron-Codorniu M, Santacreu-Vilaseca M, Seoane-Miraz D, Jad Y, et al.
Acta Neuropathol
. 2024 Sep;
148(1):45.
PMID: 39305312
Amyotrophic lateral sclerosis (ALS) is an adult-onset motor neuron disease with a mean survival time of three years. The 97% of the cases have TDP-43 nuclear depletion and cytoplasmic aggregation...
3.
Ceron-Codorniu M, Torres P, Fernandez-Bernal A, Rico-Rios S, Serrano J, Miralles M, et al.
Redox Biol
. 2024 Aug;
75:103301.
PMID: 39116527
The dysfunction of TAR DNA-binding protein 43 (TDP-43) is implicated in various neurodegenerative diseases, though the specific contributions of its toxic gain-of-function versus loss-of-function effects remain unclear. This study investigates...
4.
Berdun R, Obis E, Mota-Martorell N, Bassols A, Valent D, Serrano J, et al.
Antioxidants (Basel)
. 2024 Feb;
13(2).
PMID: 38397759
Obesity is a risk factor for highly prevalent age-related neurodegenerative diseases, the pathogenesis of whichinvolves mitochondrial dysfunction and protein oxidative damage. Lipoxidation, driven by high levels of peroxidizable unsaturated fatty...
5.
Sol J, Ortega-Bravo M, Portero-Otin M, Pinol-Ripoll G, Ribas-Ripoll V, Artigues-Barbera E, et al.
BMC Med
. 2024 Jan;
22(1):17.
PMID: 38185624
Background: Slower paces of aging are related to lower risk of developing diseases and premature death. Therefore, the greatest challenge of modern societies is to ensure that the increase in...
6.
Jove M, Mota-Martorell N, Fernandez-Bernal A, Portero-Otin M, Barja G, Pamplona R
Free Radic Biol Med
. 2023 Sep;
208:728-747.
PMID: 37748717
One of the challenges facing science/biology today is uncovering the molecular bases that support and determine animal and human longevity. Nature, in offering a diversity of animal species that differ...
7.
Serrano J, Castro-Boque E, Garcia-Carrasco A, Moran-Valero M, Gonzalez-Hedstrom D, Bermudez-Lopez M, et al.
Nutrients
. 2023 Sep;
15(17).
PMID: 37686723
The use of garlic () for treating arterial hypertension has been recognized as effective for several decades. However, tolerance to treatment is low, and several technological modifications have been developed...
8.
Portero-Otin M, de la Maza M, Uribarri J
Cells
. 2023 Jul;
12(13).
PMID: 37443718
Insulin resistance (IR) is commonly observed during aging and is at the root of many of the chronic nontransmissible diseases experienced as people grow older. Many factors may play a...
9.
Brewer M, Torres P, Ayala V, Portero-Otin M, Pamplona R, Andres-Benito P, et al.
J Neurochem
. 2023 Jul;
168(5):744-759.
PMID: 37401737
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of motor neurons in the spinal cord. Glial cells, including astrocytes and microglia, have been shown...
10.
Obis E, Sol J, Andres-Benito P, Martin-Gari M, Mota-Martorell N, Galo-Licona J, et al.
Aging Dis
. 2023 May;
14(5):1887-1916.
PMID: 37196109
Non-targeted LC-MS/MS-based lipidomic analysis was conducted in post-mortem human grey matter frontal cortex area 8 (GM) and white matter of the frontal lobe centrum semi-ovale (WM) to identify lipidome fingerprints...