Adrian Hall
Overview
Explore the profile of Adrian Hall including associated specialties, affiliations and a list of published articles.
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64
Citations
381
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Recent Articles
1.
Mittal A, Martin M, Levin E, Adams C, Yang M, Provins L, et al.
Nat Struct Mol Biol
. 2025 Mar;
PMID: 40050463
No abstract available.
2.
Poullennec K, Jnoff E, Abendroth J, Bhuma N, Calmiano M, Calmus L, et al.
J Med Chem
. 2024 Nov;
67(23):20879-20910.
PMID: 39588908
Nuak1 (NUAK family SnF1-like kinase-1) is a serine-threonine kinase and a member of the AMPK family. Interest in Nuak1 has increased over the years due to the role it plays...
3.
Bagal S, Giblin G, Hall A, Jones P
ChemMedChem
. 2024 Jul;
19(18):e202400212.
PMID: 39073753
The Biological and Medicinal Chemistry Sector (BMCS) is an important interest group within the UK's Royal Society of Chemistry (RSC). Operating through a committee of voluntary members, the main goal...
4.
Mittal A, Martin M, Levin E, Adams C, Yang M, Provins L, et al.
Nat Struct Mol Biol
. 2024 Jun;
31(12):1964-1974.
PMID: 38898101
Epilepsy is a common neurological disorder characterized by abnormal activity of neuronal networks, leading to seizures. The racetam class of anti-seizure medications bind specifically to a membrane protein found in...
5.
Hall A, Chatzopoulou M, Frost J
Bioorg Med Chem
. 2024 Apr;
104:117653.
PMID: 38579492
Carboxylic acids are key pharmacophoric elements in many molecules. They can be seen as a problem by some, due to perceived permeability challenges, potential for high plasma protein binding and...
6.
Schulze M, Scholz D, Jnoff E, Hall A, Melin J, Sands Z, et al.
ChemMedChem
. 2024 Feb;
19(7):e202300548.
PMID: 38381042
Several novel chemical series were identified that modulate glucocerebrosidase (GCase). Compounds from these series are active on glucosylceramide, unlike other known GCase modulators. We obtained GCase crystal structures with two...
7.
Ali A, Bauser M, Bertrand S, Blackaby W, Boss C, Bossart M, et al.
ChemMedChem
. 2023 Jun;
18(13):e202300127.
PMID: 37276375
The status of industrial Medicinal Chemistry was discussed with European Medicinal Chemistry Leaders from large to mid-sized pharma and CRO companies as well as biotechs. The chemical modality space has...
8.
Hall A, Abendroth J, Bolejack M, Ceska T, DellAiera S, Ellis V, et al.
ACS Med Chem Lett
. 2022 Jul;
13(7):1099-1108.
PMID: 35859861
We describe the identification and characterization of a series of covalent inhibitors of the C-terminal kinase domain (CTKD) of MSK1. The initial hit was identified via a high-throughput screening and...
9.
Tilby M, Dewez D, Pantaine L, Hall A, Martinez-Lamenca C, Willis M
ACS Catal
. 2022 May;
12(10):6060-6067.
PMID: 35633900
A plethora of drug molecules and agrochemicals contain the sulfonamide functional group. However, sulfonamides are seldom viewed as synthetically useful functional groups. To confront this limitation, a late-stage functionalization strategy...
10.
Tilby M, Dewez D, Hall A, Martinez Lamenca C, Willis M
Angew Chem Int Ed Engl
. 2021 Sep;
60(49):25680-25687.
PMID: 34558788
Methods for establishing the absolute configuration of sulfur-stereogenic aza-sulfur derivatives are scarce, often relying on cumbersome protocols and a limited pool of enantioenriched starting materials. We have addressed this by...