Adam S Crystal
Overview
Explore the profile of Adam S Crystal including associated specialties, affiliations and a list of published articles.
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12
Citations
1580
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Recent Articles
1.
Infante J, Cassier P, Gerecitano J, Witteveen P, Chugh R, Ribrag V, et al.
Clin Cancer Res
. 2016 Aug;
22(23):5696-5705.
PMID: 27542767
Purpose: Ribociclib (an oral, highly specific cyclin-dependent kinase 4/6 inhibitor) inhibits tumor growth in preclinical models with intact retinoblastoma protein (Rb). This first-in-human study investigated the MTD, recommended dose for...
2.
Hata A, Niederst M, Archibald H, Gomez-Caraballo M, Siddiqui F, Mulvey H, et al.
Nat Med
. 2016 Feb;
22(3):262-9.
PMID: 26828195
Although mechanisms of acquired resistance of epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancers to EGFR inhibitors have been identified, little is known about how resistant clones evolve during drug...
3.
Crystal A, Shaw A, Sequist L, Friboulet L, Niederst M, Lockerman E, et al.
Science
. 2014 Nov;
346(6216):1480-6.
PMID: 25394791
Targeted cancer therapies have produced substantial clinical responses, but most tumors develop resistance to these drugs. Here, we describe a pharmacogenomic platform that facilitates rapid discovery of drug combinations that...
4.
Friboulet L, Li N, Katayama R, Lee C, Gainor J, Crystal A, et al.
Cancer Discov
. 2014 Mar;
4(6):662-673.
PMID: 24675041
Unlabelled: Non-small cell lung cancers (NSCLC) harboring anaplastic lymphoma kinase (ALK) gene rearrangements invariably develop resistance to the ALK tyrosine kinase inhibitor (TKI) crizotinib. Herein, we report the first preclinical...
5.
Crystal A, Shaw A
Clin Cancer Res
. 2012 Aug;
18(17):4479-81.
PMID: 22912388
Anaplastic lymphoma kinase (ALK) gene rearrangements are found in approximately 5% of non-small cell lung carcinoma patients and confer sensitivity to ALK inhibitors such as crizotinib. The particular ALK fusion...
6.
Crystal A, Shaw A
Clin Adv Hematol Oncol
. 2011 Apr;
9(3):207-14.
PMID: 21475126
Targeted therapies aimed at inhibiting oncogenic tyrosine kinases are becoming commonplace in the treatment of cancer. The EML4-ALK fusion gene was first identified as a potentially targetable oncogenic driver in...
7.
Morais V, Brito C, Pijak D, Crystal A, Fortna R, Li T, et al.
Biochim Biophys Acta
. 2006 Aug;
1762(9):802-10.
PMID: 16938437
The gamma-secretase complex, composed of four non-covalently bound transmembrane proteins Presenilin, Nicastrin (NCT), APH-1 and PEN-2, is responsible for the intramembranous cleavage of amyloid precursor protein (APP), Notch and several...
8.
Crystal A, Morais V, Fortna R, Carlin D, Pierson T, Wilson C, et al.
Biochemistry
. 2004 Mar;
43(12):3555-63.
PMID: 15035625
The gamma-secretase complex functions to cleave several type I transmembrane proteins within their transmembrane domains. These include the amyloid precursor protein, which is central to Alzheimer's disease pathogenesis, as well...
9.
Fortna R, Crystal A, Morais V, Pijak D, Lee V, Doms R
J Biol Chem
. 2003 Nov;
279(5):3685-93.
PMID: 14593096
APH-1, presenilin, nicastrin, and Pen-2 are proteins with varying membrane topologies that compose the gamma-secretase complex, which is responsible for the intramembrane proteolysis of several substrates including the amyloid precursor...
10.
Crystal A, Giasson B, Crowe A, Kung M, Zhuang Z, Trojanowski J, et al.
J Neurochem
. 2003 Sep;
86(6):1359-68.
PMID: 12950445
Proteinaceous inclusions with amyloidogenic properties are a common link between many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Histological and in vitro studies of amyloid fibrils have advanced the...