Adam R Brown
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Explore the profile of Adam R Brown including associated specialties, affiliations and a list of published articles.
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Citations
695
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Recent Articles
1.
Brown A, Freedman M, Lin H, Susskind L
Nature
. 2023 Oct;
622(7981):58-62.
PMID: 37794268
In physics, two systems that radically differ at short scales can exhibit strikingly similar macroscopic behaviour: they are part of the same long-distance universality class. Here we apply this viewpoint...
2.
Allais C, Bernhardson D, Brown A, Chinigo G, Desrosiers J, DiRico K, et al.
Org Process Res Dev
. 2023 Aug;
PMID: 37552749
Lufotrelvir was designed as a first in class 3CL protease inhibitor to treat COVID-19. Development of lufotrelvir was challenged by its relatively poor stability due to its propensity to epimerize...
3.
4.
Brown A, Alhallak I, Simmen R, Melnyk S, Heard-Lipsmeyer M, Montales M, et al.
Cancers (Basel)
. 2022 Apr;
14(7).
PMID: 35406507
Obesity, oxidative stress, and inflammation are risk factors for hepatocellular carcinoma (HCC). We examined, in mice, the effects of Krüppel-like factor 9 (KLF9) knockout on: adiposity, hepatic and systemic oxidative...
5.
Brown A, Ettefagh K, Todd D, Cole P, Egan J, Foil D, et al.
J Ethnopharmacol
. 2020 Nov;
267:113533.
PMID: 33137433
Ethnopharmacological Relevance: Secondary metabolites play a critical role in plant defense against disease and are of great importance to ethnomedicine. Bacterial efflux pumps are active transport proteins that bacterial cells...
6.
Brown A
Phys Rev Lett
. 2019 Jan;
121(25):251601.
PMID: 30608834
A model of cosmological inflation is proposed in which field space is a hyperbolic plane. The inflaton never slow-rolls, and instead orbits the bottom of the potential, buoyed by a...
7.
Nickolls S, Gurrell R, van Amerongen G, Kammonen J, Cao L, Brown A, et al.
Br J Pharmacol
. 2017 Dec;
175(4):708-725.
PMID: 29214652
Background And Purpose: Benzodiazepines, non-selective positive allosteric modulators (PAMs) of GABA receptors, have significant side effects that limit their clinical utility. As many of these side effects are mediated by...
8.
Etherington L, Mihalik B, Palvolgyi A, Ling I, Pallagi K, Kertesz S, et al.
Neuropharmacology
. 2017 Aug;
125:353-364.
PMID: 28807671
In the mammalian central nervous system (CNS) GABA receptors (GABARs) mediate neuronal inhibition and are important therapeutic targets. GABARs are composed of 5 subunits, drawn from 19 proteins, underpinning expression...
9.
Leyte-Lugo M, Britton E, Foil D, Brown A, Todd D, Rivera-Chavez J, et al.
Phytochem Lett
. 2017 Jul;
20:54-60.
PMID: 28736584
The study presented herein constitutes an extensive investigation of constituents in L. (Ranunculaceae) leaves. It describes the isolation and identification of two previously unknown compounds, 3,4-dimethoxy-2-(methoxycarbonyl)benzoic acid () and 3,5,3'-trihydroxy-7,4'-dimethoxy-6,8--dimethyl-flavone...
10.
Brown A, Roberts D, Susskind L, Swingle B, Zhao Y
Phys Rev Lett
. 2016 May;
116(19):191301.
PMID: 27232013
We conjecture that the quantum complexity of a holographic state is dual to the action of a certain spacetime region that we call a Wheeler-DeWitt patch. We illustrate and test...