Jeremy J Lambert
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Explore the profile of Jeremy J Lambert including associated specialties, affiliations and a list of published articles.
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72
Citations
3382
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Recent Articles
1.
Belelli D, Lambert J, Wan M, Monteiro A, Nutt D, Swinny J
Brain
. 2024 Dec;
PMID: 39716883
Convergent data, across species, paint a compelling picture of the critical role of the gut and its resident microbiota in several brain functions and disorders. The chemicals mediating communication along...
2.
Baldwin A, Foley D, Collins R, Lee H, Jones D, Wahab B, et al.
J Med Chem
. 2024 Dec;
68(1):719-752.
PMID: 39711116
LIMKs are serine/threonine and tyrosine kinases responsible for controlling cytoskeletal dynamics as key regulators of actin stability, ensuring synaptic health through normal synaptic bouton structure and function. However, LIMK1 overactivation...
3.
Mitchell S, Phillips G, Tench B, Li Y, Belelli D, Martin S, et al.
Biomolecules
. 2024 Apr;
14(4).
PMID: 38672476
The recent approval of formulations of the endogenous neurosteroid allopregnanolone (brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat postpartum depression (PPD) has encouraged further research to elucidate why...
4.
Macpherson T, Dixon C, Robertson J, Sindarto M, Janak P, Belelli D, et al.
eNeuro
. 2023 Aug;
10(8).
PMID: 37553242
Extrasynaptic GABA receptors (GABARs) composed of α4, β, and δ subunits mediate GABAergic tonic inhibition and are potential molecular targets in the modulation of behavioral responses to natural and drug...
5.
Singleton S, Sneddon C, Bakina A, Lambert J, Hales T
Pain
. 2023 May;
164(10):2253-2264.
PMID: 37171192
Exposure to severely stressful events during childhood is associated with poor health outcomes in later life, including chronic pain and substance use disorder. However, the mediators and mechanisms are unclear....
6.
Spedding M, Sebban C, Jay T, Rocher C, Tesolin-Decros B, Chazot P, et al.
Cells
. 2022 Apr;
11(7).
PMID: 35406745
Dysfunction in the hippocampus-prefrontal cortex (H-PFC) circuit is a critical determinant of schizophrenia. Screening of pyridazinone-risperidone hybrids on this circuit revealed EGIS 11150 (S 36549). EGIS 11150 induced theta rhythm...
7.
Bolton J, Short A, Othy S, Kooiker C, Shao M, Gunn B, et al.
Cell Rep
. 2022 Mar;
38(13):110600.
PMID: 35354026
Several mental illnesses, characterized by aberrant stress reactivity, often arise after early-life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit maturation, provoking these enduring vulnerabilities. We...
8.
Belelli D, Hales T, Lambert J, Luscher B, Olsen R, Peters J, et al.
IUPHAR BPS Guide Pharm CITE
. 2022 Jan;
2021(3).
PMID: 35005623
The GABA receptor is a ligand-gated ion channel of the Cys-loop family that includes the nicotinic acetylcholine, 5-HT and strychnine-sensitive glycine receptors. GABA receptor-mediated inhibition within the CNS occurs by...
9.
Belelli D, Phillips G, Atack J, Lambert J
J Neuroendocrinol
. 2021 Oct;
34(2):e13045.
PMID: 34644812
Studies in the 1980s revealed endogenous metabolites of progesterone and deoxycorticosterone to be potent, efficacious, positive allosteric modulators (PAMs) of the GABA receptor (GABA R). The discovery that such steroids...
10.
Kelly L, Seifi M, Ma R, Mitchell S, Rudolph U, Viola K, et al.
Neuropathol Appl Neurobiol
. 2020 Oct;
47(4):488-505.
PMID: 33119191
Aims: Amyloid β-oligomers (AβO) are potent modulators of Alzheimer's pathology, yet their impact on one of the earliest brain regions to exhibit signs of the condition, the locus coeruleus (LC),...