Adam M Gilbert
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Explore the profile of Adam M Gilbert including associated specialties, affiliations and a list of published articles.
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40
Citations
771
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Recent Articles
1.
Zhang Y, Liu Z, Hirschi M, Brodsky O, Johnson E, Won S, et al.
Nat Chem Biol
. 2024 Sep;
21(3):420-431.
PMID: 39294320
More than half of the ~20,000 protein-encoding human genes have paralogs. Chemical proteomics has uncovered many electrophile-sensitive cysteines that are exclusive to subsets of paralogous proteins. Here we explore whether...
2.
Zhang Y, Liu Z, Hirschi M, Brodsky O, Johnson E, Won S, et al.
bioRxiv
. 2024 Jan;
PMID: 38293178
More than half of the ~20,000 protein-encoding human genes have at least one paralog. Chemical proteomics has uncovered many electrophile-sensitive cysteines that are exclusive to a subset of paralogous proteins....
3.
Bartlett D, Gilbert A
Chem Soc Rev
. 2022 Apr;
51(9):3477-3486.
PMID: 35438107
Targeted protein degradation has emerged from the chemical biology toolbox as one of the most exciting areas for novel therapeutic development across the pharmaceutical industry. The ability to induce the...
4.
Bai G, OConnell T, Brodney M, Butler C, Czabaniuk L, Gilbert A, et al.
ACS Med Chem Lett
. 2021 Oct;
12(10):1585-1588.
PMID: 34676040
The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidines which undergo an acid-mediated intramolecular ring-opening decomposition via nucleophilic attack...
5.
Schiemer J, Horst R, Meng Y, Montgomery J, Xu Y, Feng X, et al.
Nat Chem Biol
. 2020 Nov;
17(2):152-160.
PMID: 33199914
Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a...
6.
Bartlett D, Gilbert A
J Pharmacokinet Pharmacodyn
. 2020 Oct;
48(1):149-163.
PMID: 33090299
Bispecific protein degraders (BPDs) engage the ubiquitin-proteasome system (UPS) to catalytically degrade intracellular proteins through the formation of ternary complexes with the target protein and E3 ubiquitin ligases. Here, we...
7.
Zorba A, Nguyen C, Xu Y, Starr J, Borzilleri K, Smith J, et al.
Proc Natl Acad Sci U S A
. 2018 Jul;
115(31):E7285-E7292.
PMID: 30012605
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that simultaneously bind to a target protein and an E3 ligase, thereby leading to ubiquitination and subsequent degradation of the target. They...
8.
Che Y, Gilbert A, Shanmugasundaram V, Noe M
Bioorg Med Chem Lett
. 2018 Jul;
28(15):2585-2592.
PMID: 29980357
The drugable proteome is limited by the number of functional binding sites that can bind small molecules and respond with a therapeutic effect. Orthosteric and allosteric modulators of enzyme function...
9.
McAllister L, Butler C, Mente S, ONeil S, Fonseca K, Piro J, et al.
J Med Chem
. 2018 Mar;
61(7):3008-3026.
PMID: 29498843
Monoacylglycerol lipase (MAGL) inhibition provides a potential treatment approach to neuroinflammation through modulation of both the endocannabinoid pathway and arachidonoyl signaling in the central nervous system (CNS). Herein we report...
10.
Unwalla R, Mousseau J, Fadeyi O, Choi C, Parris K, Hu B, et al.
J Med Chem
. 2017 Jul;
60(14):6451-6457.
PMID: 28696695
In an effort to find new and safer treatments for osteoporosis and frailty, we describe a novel series of selective androgen receptor modulators (SARMs). Using a structure-based approach, we identified...