Adam Institoris
Overview
Explore the profile of Adam Institoris including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
481
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Recent Articles
1.
Vandal M, Institoris A, Reveret L, Korin B, Gunn C, Hirai S, et al.
Neuron
. 2025 Feb;
PMID: 39892386
Polymorphisms in CD2-associated protein (CD2AP) predispose to Alzheimer's disease (AD), but the underlying mechanisms remain unknown. Here, we show that loss of CD2AP in cerebral blood vessels is associated with...
2.
Renden R, Institoris A, Sharma K, Tran C
Commun Biol
. 2024 Mar;
7(1):287.
PMID: 38459113
Dynamic changes in astrocyte Ca are recognized as contributors to functional hyperemia, a critical response to increased neuronal activity mediated by a process known as neurovascular coupling (NVC). Although the...
3.
Renden R, Institoris A, Sharma K, Tran C
Res Sq
. 2023 Jul;
PMID: 37502946
Dynamic changes in astrocyte Ca are recognized as contributors to functional hyperemia, a critical response to increased neuronal activity mediated by a process known as neurovascular coupling (NVC). Although the...
4.
Institoris A, Vandal M, Peringod G, Catalano C, Tran C, Yu X, et al.
Nat Commun
. 2022 Dec;
13(1):7872.
PMID: 36550102
Functional hyperemia occurs when enhanced neuronal activity signals to increase local cerebral blood flow (CBF) to satisfy regional energy demand. Ca elevation in astrocytes can drive arteriole dilation to increase...
5.
Hiess F, Yao J, Song Z, Sun B, Zhang Z, Huang J, et al.
Commun Biol
. 2022 Mar;
5(1):183.
PMID: 35233070
Ryanodine receptor 2 (RyR2) is abundantly expressed in the heart and brain. Mutations in RyR2 are associated with both cardiac arrhythmias and intellectual disability. While the mechanisms of RyR2-linked arrhythmias...
6.
Haidey J, Peringod G, Institoris A, Gorzo K, Nicola W, Vandal M, et al.
Cell Rep
. 2021 Aug;
36(5):109405.
PMID: 34348138
Very-low-frequency oscillations in microvascular diameter cause fluctuations in oxygen delivery that are important for fueling the brain and for functional imaging. However, little is known about how the brain regulates...
7.
Institoris A, Gordon G
Nat Neurosci
. 2021 Apr;
24(5):615-617.
PMID: 33883740
No abstract available.
8.
Balasubramanian P, Kiss T, Tarantini S, Nyul-Toth A, Ahire C, Yabluchanskiy A, et al.
Am J Physiol Heart Circ Physiol
. 2020 Dec;
320(2):H740-H761.
PMID: 33337961
Over two-thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between the degree of adiposity and cognitive dysfunction in...
9.
Institoris A, Murphy-Royal C, Tarantini S, Yabluchanskiy A, Haidey J, Csiszar A, et al.
Geroscience
. 2020 Oct;
43(1):197-212.
PMID: 33094399
Whole brain irradiation (WBI) therapy is an important treatment for brain metastases and potential microscopic malignancies. WBI promotes progressive cognitive dysfunction in over half of surviving patients, yet, the underlying...
10.
Yao J, Sun B, Institoris A, Zhan X, Guo W, Song Z, et al.
Cell Rep
. 2020 Sep;
32(12):108169.
PMID: 32966798
Neuronal hyperactivity is an early primary dysfunction in Alzheimer's disease (AD) in humans and animal models, but effective neuronal hyperactivity-directed anti-AD therapeutic agents are lacking. Here we define a previously...