Grant R Gordon
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Explore the profile of Grant R Gordon including associated specialties, affiliations and a list of published articles.
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27
Citations
761
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Recent Articles
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2.
Mishra A, Gordon G, MacVicar B, Newman E
Cold Spring Harb Perspect Biol
. 2024 Feb;
16(4.
PMID: 38316553
Astrocytes play an important role in controlling microvascular diameter and regulating local cerebral blood flow (CBF) in several physiological and pathological scenarios. Neurotransmitters released from active neurons evoke Ca increases...
3.
Nasu Y, Aggarwal A, Le G, Vo C, Kambe Y, Wang X, et al.
Nat Commun
. 2023 Oct;
14(1):6598.
PMID: 37891202
L-Lactate is increasingly appreciated as a key metabolite and signaling molecule in mammals. However, investigations of the inter- and intra-cellular dynamics of L-lactate are currently hampered by the limited selection...
4.
Institoris A, Vandal M, Peringod G, Catalano C, Tran C, Yu X, et al.
Nat Commun
. 2022 Dec;
13(1):7872.
PMID: 36550102
Functional hyperemia occurs when enhanced neuronal activity signals to increase local cerebral blood flow (CBF) to satisfy regional energy demand. Ca elevation in astrocytes can drive arteriole dilation to increase...
5.
OGallagher K, Rosentreter R, Soriano J, Roomi A, Saleem S, Lam T, et al.
Circ Res
. 2022 Nov;
131(12):952-961.
PMID: 36349758
Background: Neurovascular coupling (NVC) is a key process in cerebral blood flow regulation. NVC ensures adequate brain perfusion to changes in local metabolic demands. Neuronal nitric oxide synthase (nNOS) is...
6.
Hiess F, Yao J, Song Z, Sun B, Zhang Z, Huang J, et al.
Commun Biol
. 2022 Mar;
5(1):183.
PMID: 35233070
Ryanodine receptor 2 (RyR2) is abundantly expressed in the heart and brain. Mutations in RyR2 are associated with both cardiac arrhythmias and intellectual disability. While the mechanisms of RyR2-linked arrhythmias...
7.
Gorzo K, Gordon G
Neurophotonics
. 2022 Feb;
9(2):021907.
PMID: 35211642
Astrocytes integrate information from neurons and the microvasculature to coordinate brain activity and metabolism. Using a variety of calcium-dependent cellular mechanisms, these cells impact numerous aspects of neurophysiology in health...
8.
Nasu Y, Murphy-Royal C, Wen Y, Haidey J, Molina R, Aggarwal A, et al.
Nat Commun
. 2021 Dec;
12(1):7058.
PMID: 34873165
L-Lactate, traditionally considered a metabolic waste product, is increasingly recognized as an important intercellular energy currency in mammals. To enable investigations of the emerging roles of intercellular shuttling of L-lactate,...
9.
Lau B, Murphy-Royal C, Kaur M, Qiao M, Bains J, Gordon G, et al.
Cell Rep
. 2021 Aug;
36(7):109563.
PMID: 34407401
Overconsumption of highly palatable, energy-dense food is considered a key driver of the obesity pandemic. The orbitofrontal cortex (OFC) is critical for reward valuation of gustatory signals, yet how the...
10.
Haidey J, Peringod G, Institoris A, Gorzo K, Nicola W, Vandal M, et al.
Cell Rep
. 2021 Aug;
36(5):109405.
PMID: 34348138
Very-low-frequency oscillations in microvascular diameter cause fluctuations in oxygen delivery that are important for fueling the brain and for functional imaging. However, little is known about how the brain regulates...