Adam G Hendricks
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Explore the profile of Adam G Hendricks including associated specialties, affiliations and a list of published articles.
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25
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719
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Recent Articles
1.
Swaim G, Glomb O, Xie Y, Emerson C, Li Z, Beaudet D, et al.
bioRxiv
. 2025 Feb;
PMID: 39990487
Axons experience strong mechanical forces due to animal movement. While these forces serve as sensory cues in mechanosensory neurons, their impact on other neuron types remains poorly defined. Here, we...
2.
Sebastien M, Paquette A, Prowse E, Hendricks A, Brouhard G
Nat Commun
. 2025 Feb;
16(1):1749.
PMID: 39966472
Doublecortin is a neuronal microtubule-associated protein that regulates microtubule structure in neurons. Mutations in Doublecortin cause lissencephaly and subcortical band heterotopia by impairing neuronal migration. We use CRISPR/Cas9 to knock-out...
3.
Prowse E, Turkalj B, Gursu L, Hendricks A
Biochemistry
. 2025 Feb;
64(4):760-769.
PMID: 39909923
A dynamic network of scaffolding molecules, adaptor proteins, and motor proteins work together to orchestrate the movement of proteins, mRNA, and vesicular cargoes. Defects in intracellular transport can often lead...
4.
Sebastien M, Paquette A, Ferotin L, Hendricks A, Brouhard G
Mol Biol Cell
. 2024 Nov;
36(1):mr1.
PMID: 39602292
In neurons, patterns of different microtubule types are essential for neurite extension and nucleokinesis. Cellular model systems such as rodent primary cultures and induced pluripotent stem cells (iPSC)-derived neurons have...
5.
Nagpal S, Swaminathan K, Beaudet D, Verdier M, Wang S, Berger C, et al.
Cell Rep
. 2024 Aug;
43(8):114649.
PMID: 39159044
Each cargo in a cell employs a unique set of motor proteins for its transport. To dissect the roles of each type of motor, we developed optogenetic inhibitors of endogenous...
6.
Beaudet D, Berger C, Hendricks A
J Biol Chem
. 2024 Apr;
300(6):107323.
PMID: 38677516
Organelles and vesicular cargoes are transported by teams of kinesin and dynein motors along microtubules. We isolated endocytic organelles from cells at different stages of maturation and reconstituted their motility...
7.
Nithianantham S, Iwanski M, Gaska I, Pandey H, Bodrug T, Inagaki S, et al.
Mol Biol Cell
. 2023 Aug;
34(11):ar111.
PMID: 37610838
Kinesin-5 crosslinks and slides apart microtubules to assemble, elongate, and maintain the mitotic spindle. Kinesin-5 is a tetramer, where two N-terminal motor domains are positioned at each end of the...
8.
Prowse E, Chaudhary A, Sharon D, Hendricks A
Biophys J
. 2023 Feb;
122(7):1168-1184.
PMID: 36772794
Huntingtin (HTT) is a scaffolding protein that recruits motor proteins to vesicular cargoes, enabling it to regulate kinesin-1, dynein, and myosin-VI-dependent transport. To maintain the native stoichiometry of HTT with...
9.
Beaudet D, Hendricks A
Methods Mol Biol
. 2023 Jan;
2623:113-132.
PMID: 36602683
In this chapter, we describe methods for reconstituting and analyzing the transport of isolated endogenous cargoes in vitro. Intracellular cargoes are transported along microtubules by teams of kinesin and dynein...
10.
Balabanian L, Lessard D, Swaminathan K, Yaninska P, Sebastien M, Wang S, et al.
Mol Biol Cell
. 2022 Sep;
33(13):ar128.
PMID: 36129768
Microtubule-associated proteins (MAPs) modulate the motility of kinesin and dynein along microtubules to control the transport of vesicles and organelles. The neuronal MAP tau inhibits kinesin-dependent transport. Phosphorylation of tau...