Adam E Mullick
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Explore the profile of Adam E Mullick including associated specialties, affiliations and a list of published articles.
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73
Citations
2297
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Recent Articles
1.
Peng X, Lian Z, OBrien V, Xiao J, Litchfield B, Dai Perrard X, et al.
J Lipid Res
. 2025 Feb;
:100763.
PMID: 39988193
Hypertriglyceridemia (HTG), particularly in combined hyperlipidemia, increases risk for atherosclerotic cardiovascular disease, but the underlying mechanisms remain incompletely understood. We sought to determine contributions of circulating monocytes to atherosclerosis associated...
2.
Amioka N, Franklin M, Kukida M, Zhu L, Moorleghen J, Howatt D, et al.
Arterioscler Thromb Vasc Biol
. 2024 Nov;
45(1):74-89.
PMID: 39569521
Background: Pharmacological inhibition of megalin (also known as LRP2 [low-density lipoprotein receptor-related protein-2]) attenuates atherosclerosis in hypercholesterolemic mice. Since megalin is abundant in renal proximal tubule cells (PTCs), the purpose...
3.
Bortolin R, Nawar F, Park C, Trembley M, Prondzynski M, Sweat M, et al.
Circulation
. 2024 Aug;
150(15):1199-1210.
PMID: 39155863
Background: Calmodulinopathies are rare inherited arrhythmia syndromes caused by dominant heterozygous variants in , , or , which each encode the identical CaM (calmodulin) protein. We hypothesized that antisense oligonucleotide...
4.
Amioka N, Franklin M, Kukida M, Zhu L, Moorleghen J, Howatt D, et al.
bioRxiv
. 2024 May;
PMID: 38798535
Background: Pharmacological inhibition of megalin (also known as low-density lipoprotein receptor-related protein 2: LRP2) attenuates atherosclerosis in hypercholesterolemic mice. Since megalin is abundant in renal proximal tubule cells (PTCs), the...
5.
Cervantes J, Koska J, Kramer F, Akilesh S, Alpers C, Mullick A, et al.
JCI Insight
. 2024 May;
9(12).
PMID: 38743496
Diabetes increases the risk of both cardiovascular disease and kidney disease. Notably, most of the excess cardiovascular risk in people with diabetes is in those with kidney disease. Apolipoprotein C3...
6.
Watts S, Mullick A, Garver H, Orr A, Fink G
Am Heart J Plus
. 2024 Apr;
22:100205.
PMID: 38558911
Study Objective: To test the hypothesis that a high fat (HF) diet stimulates dependence on chemerin for blood pressure regulation. Design: Blood pressure in male Sprague Dawley rats fed a...
7.
Shridas P, Ji A, Trumbauer A, Noffsinger V, Meredith L, de Beer F, et al.
Atherosclerosis
. 2024 Mar;
391:117492.
PMID: 38461759
Background And Aims: Obesity increases the risk for abdominal aortic aneurysms (AAA) in humans and enhances angiotensin II (AngII)-induced AAA formation in C57BL/6 mice. We reported that deficiency of Serum...
8.
Shridas P, Ji A, Trumbauer A, Noffsinger V, Meredith L, de Beer F, et al.
bioRxiv
. 2023 Sep;
PMID: 37662383
Objective: Obesity increases the risk for abdominal aortic aneurysms (AAA) in humans and enhances angiotensin II (AngII)-induced AAA formation in C57BL/6 mice. Obesity is also associated with increases in serum...
9.
Wabel E, Orr A, Flood E, Thompson J, Xie H, Demireva E, et al.
Am J Physiol Heart Circ Physiol
. 2023 Jun;
325(1):H172-H186.
PMID: 37294893
The adipokine chemerin may support blood pressure, evidenced by a fall in mean arterial pressure after whole body antisense oligonucleotide (ASO)-mediated knockdown of chemerin protein in rat models of normal...
10.
Ye D, Wu C, Cai L, Howatt D, Liang C, Katsumata Y, et al.
Glob Transl Med
. 2023 Jun;
2(1).
PMID: 37293374
Hepatocyte-derived angiotensinogen (AGT) is the precursor of angiotensin II (AngII). We determined the effects of hepatocyte-specific (-acetylgalactosamine-conjugated) antisense oligonucleotides targeting AGT (GalNAc AGT ASO) on AngII-mediated blood pressure (BP) regulation...