Adam E Mullick
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Explore the profile of Adam E Mullick including associated specialties, affiliations and a list of published articles.
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73
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2297
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Recent Articles
11.
Blood Levels of Angiotensinogen and Hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA)
Trainor P, Brambatti M, Carlisle S, Mullick A, Shah S, Kahlon T, et al.
J Am Coll Cardiol
. 2023 Mar;
81(13):1248-1259.
PMID: 36990544
Background: Angiotensinogen is the proximal precursor of the angiotensin peptide hormones of the renin-angiotensin-aldosterone system (RAAS). Clinical trials are ongoing targeting angiotensinogen for the treatment of hypertension and heart failure....
12.
Hsu C, Shao B, Kanter J, He Y, Vaisar T, Witztum J, et al.
Nat Immunol
. 2023 Feb;
24(3):408-411.
PMID: 36781985
No abstract available.
13.
Zhang J, Au D, Sawada H, Franklin M, Moorleghen J, Howatt D, et al.
JCI Insight
. 2022 Dec;
8(2).
PMID: 36472907
Vascular smooth muscle cells (vSMCs) exert a critical role in sensing and maintaining vascular integrity. These cells abundantly express the low-density lipoprotein receptor-related protein 1 (LRP1), a large endocytic signaling...
14.
Oluwadare J, Cabodevilla A, Son N, Hu Y, Mullick A, Verano M, et al.
J Lipid Res
. 2022 Sep;
63(11):100274.
PMID: 36115595
Lipid accumulation in nonadipose tissues can cause lipotoxicity, leading to cell death and severe organ dysfunction. Adipose triglyceride lipase (ATGL) deficiency causes human neutral lipid storage disease and leads to...
15.
Sawada H, Ohno-Urabe S, Ye D, Franklin M, Moorleghen J, Howatt D, et al.
Arterioscler Thromb Vasc Biol
. 2022 Aug;
42(10):1254-1261.
PMID: 36004642
Background: Cross-linking of lysine residues in elastic and collagen fibers is a vital process in aortic development. Inhibition of lysyl oxidase by BAPN (β-aminopropionitrile) leads to thoracic aortopathies in mice....
16.
Orr A, Liu K, Mullick A, Huang X, Watts S
Biomedicines
. 2022 Jul;
10(7).
PMID: 35884940
Nanoparticles (NPs) can enable delivery of a drug to a targeted tissue. Previous studies have shown that an NP utilizing an adipose targeting sequence (ATS) peptide in conjunction with a...
17.
Ramms B, Patel S, Sun X, Pessentheiner A, Ducasa G, Mullick A, et al.
JCI Insight
. 2022 Jun;
7(13).
PMID: 35653195
Apolipoprotein C-III (apoC-III) is a critical regulator of triglyceride metabolism and correlates positively with hypertriglyceridemia and cardiovascular disease (CVD). It remains unclear if therapeutic apoC-III lowering reduces CVD risk and...
18.
Kuo C, Nikan M, Yeh S, Chappell A, Tanowitz M, Seth P, et al.
Nucleic Acid Ther
. 2022 May;
32(4):300-311.
PMID: 35612431
We evaluated the potential of AGTR1, the principal receptor for angiotensin II (Ang II) and a member of the G protein-coupled receptor family, for targeted delivery of antisense oligonucleotides (ASOs)...
19.
Eijgenraam T, Stege N, Oliveira Nunes Teixeira V, de Brouwer R, Schouten E, Grote Beverborg N, et al.
Int J Mol Sci
. 2022 Mar;
23(5).
PMID: 35269571
Inherited cardiomyopathy caused by the p.(Arg14del) pathogenic variant of the phospholamban () gene is characterized by intracardiomyocyte PLN aggregation and can lead to severe dilated cardiomyopathy. We recently reported that...
20.
Ye D, Yang X, Ren L, Lu H, Sun Y, Lin H, et al.
Front Cardiovasc Med
. 2022 Jan;
8:725203.
PMID: 35004870
Elevated plasma cholesterol concentrations contributes to ischemic cardiovascular diseases. Recently, we showed that inhibiting hepatic (pro)renin receptor [(P)RR] attenuated diet-induced hypercholesterolemia and hypertriglyceridemia in low-density lipoprotein receptor (LDLR) deficient mice....