Adam Burkholder
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Explore the profile of Adam Burkholder including associated specialties, affiliations and a list of published articles.
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831
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Recent Articles
1.
Mack J, Burkholder A, Akhtari F, House J, Sovio U, Smith G, et al.
HGG Adv
. 2024 Nov;
6(1):100385.
PMID: 39580622
Genetic factors related to pregnancy-related traits are understudied, especially in ancestrally diverse cohorts. To assess maternal contributions to hypertensive disorders of pregnancy (HDP), we performed a multi-ancestry genome-wide association study...
2.
Bhawsinghka N, Burkholder A, Schaaper R
DNA Repair (Amst)
. 2023 Feb;
123:103462.
PMID: 36738688
Mutation is a phenomenon inescapable for all life-forms, including bacteria. While bacterial mutation rates are generally low due to the operation of error-avoidance systems, sometimes they are elevated by many...
3.
Lee M, Joehanes R, McCartney D, Kho M, Huls A, Wyss A, et al.
Epigenomics
. 2023 Jan;
14(23):1479-1492.
PMID: 36700736
To identify differential methylation related to prescribed opioid use. This study examined whether blood DNA methylation, measured using Illumina arrays, differs by recent opioid medication use in four population-based cohorts....
4.
Akhtari F, Lloyd D, Burkholder A, Tong X, House J, Lee E, et al.
Diabetes Care
. 2022 Nov;
46(5):929-937.
PMID: 36383734
Objective: Environmental exposures may have greater predictive power for type 2 diabetes than polygenic scores (PGS). Studies examining environmental risk factors, however, have included only individuals with European ancestry, limiting...
5.
Bushel P, Ward J, Burkholder A, Li J, Anchang B
Sci Rep
. 2022 Jan;
12(1):1393.
PMID: 35082309
The interplay between genes harboring single nucleotide polymorphisms (SNPs) is vital to better understand underlying contributions to the etiology of breast cancer. Much attention has been paid to epistasis between...
6.
Kiktev D, Dominska M, Zhang T, Dahl J, Stepchenkova E, Mieczkowski P, et al.
Nucleic Acids Res
. 2021 May;
49(10):5623-5636.
PMID: 34019669
Iron-sulfur clusters (4Fe-4S) exist in many enzymes concerned with DNA replication and repair. The contribution of these clusters to enzymatic activity is not fully understood. We identified the MET18 (MMS19)...
7.
Lujan S, Longley M, Humble M, Lavender C, Burkholder A, Blakely E, et al.
Genome Biol
. 2020 Sep;
21(1):248.
PMID: 32943091
Background: Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease. Results: To decipher connections between...
8.
Burkholder A, Akrobetu D, Pandiri A, Ton K, Kim S, Labow B, et al.
Breast Cancer Res
. 2020 May;
22(1):44.
PMID: 32393308
Background: Early life environmental exposures affect breast development and breast cancer risk in adulthood. The breast is particularly vulnerable during puberty when mammary epithelial cells proliferate exponentially. In overweight/obese (OB)...
9.
Aden K, Bartsch K, Dahl J, Reijns M, Esser D, Sheibani-Tezerji R, et al.
Gastroenterology
. 2018 Oct;
156(1):145-159.e19.
PMID: 30273559
Background & Aims: RNase H2 is a holoenzyme, composed of 3 subunits (ribonuclease H2 subunits A, B, and C), that cleaves RNA:DNA hybrids and removes mis-incorporated ribonucleotides from genomic DNA...
10.
Pai A, Henriques T, McCue K, Burkholder A, Adelman K, Burge C
Elife
. 2017 Dec;
6.
PMID: 29280736
Production of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reaction requires definition of splice sites, which are initially recognized in either intron-spanning ('intron definition') or exon-spanning...