Daniel A Gilchrist
Overview
Explore the profile of Daniel A Gilchrist including associated specialties, affiliations and a list of published articles.
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16
Citations
1827
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Recent Articles
1.
Snyder M, Gingeras T, Moore J, Weng Z, Gerstein M, Ren B, et al.
Nature
. 2022 Apr;
605(7909):E4.
PMID: 35474002
No abstract available.
2.
Snyder M, Gingeras T, Moore J, Weng Z, Gerstein M, Ren B, et al.
Nature
. 2020 Jul;
583(7818):693-698.
PMID: 32728248
The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical...
3.
Lavender C, Cannady K, Hoffman J, Trotter K, Gilchrist D, Bennett B, et al.
PLoS Genet
. 2016 Aug;
12(8):e1006224.
PMID: 27487356
Antisense transcription is a prevalent feature at mammalian promoters. Previous studies have primarily focused on antisense transcription initiating upstream of genes. Here, we characterize promoter-proximal antisense transcription downstream of gene...
4.
Scruggs B, Gilchrist D, Nechaev S, Muse G, Burkholder A, Fargo D, et al.
Mol Cell
. 2015 Jun;
58(6):1101-12.
PMID: 26028540
Anti-sense transcription originating upstream of mammalian protein-coding genes is a well-documented phenomenon, but remarkably little is known about the regulation or function of anti-sense promoters and the non-coding RNAs they...
5.
Schroder S, Herker E, Itzen F, He D, Thomas S, Gilchrist D, et al.
Mol Cell
. 2013 Nov;
52(3):314-24.
PMID: 24207025
Lysine acetylation regulates transcription by targeting histones and nonhistone proteins. Here we report that the central regulator of transcription, RNA polymerase II, is subject to acetylation in mammalian cells. Acetylation...
6.
Henriques T, Gilchrist D, Nechaev S, Bern M, Muse G, Burkholder A, et al.
Mol Cell
. 2013 Nov;
52(4):517-28.
PMID: 24184211
Metazoan gene expression is often regulated after the recruitment of RNA polymerase II (Pol II) to promoters, through the controlled release of promoter-proximally paused Pol II into productive RNA synthesis....
7.
Fromm G, Gilchrist D, Adelman K
Cell
. 2013 May;
153(4):930-930.e1.
PMID: 23663787
No abstract available.
8.
Core L, Waterfall J, Gilchrist D, Fargo D, Kwak H, Adelman K, et al.
Cell Rep
. 2012 Oct;
2(4):1025-35.
PMID: 23062713
Recent genome-wide studies in metazoans have shown that RNA polymerase II (Pol II) accumulates to high densities on many promoters at a rate-limited step in transcription. However, the status of...
9.
Gilchrist D, Fromm G, Dos Santos G, Pham L, McDaniel I, Burkholder A, et al.
Genes Dev
. 2012 May;
26(9):933-44.
PMID: 22549956
The expression of many metazoan genes is regulated through controlled release of RNA polymerase II (Pol II) that has paused during early transcription elongation. Pausing is highly enriched at genes...
10.
Gilchrist D, Adelman K
Biochim Biophys Acta
. 2012 Mar;
1819(7):700-6.
PMID: 22406341
Altering gene expression in response to stimuli is a pivotal mechanism through which organisms execute developmental programs and respond to changes in their environment. Packaging of promoter DNA into chromatin...