Adam Amsterdam
Overview
Explore the profile of Adam Amsterdam including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
3004
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Recent Articles
1.
Phelps G, Amsterdam A, Hagen H, Garcia N, Lees J
Pigment Cell Melanoma Res
. 2022 Jul;
35(5):539-547.
PMID: 35869673
Uveal melanoma (UM) is the most common primary malignancy of the adult eye but lacks any FDA-approved therapy for the deadly metastatic disease. Thus, there is a great need to...
2.
Phelps G, Hagen H, Amsterdam A, Lees J
Proc Natl Acad Sci U S A
. 2022 May;
119(19):e2107006119.
PMID: 35512098
Cutaneous melanoma (CM) and uveal melanoma (UM) both originate from the melanocytic lineage but are primarily driven by distinct oncogenic drivers, BRAF/NRAS or GNAQ/GNA11, respectively. The melanocytic master transcriptional regulator,...
3.
Perez D, Henle A, Amsterdam A, Hagen H, Lees J
Pigment Cell Melanoma Res
. 2018 Mar;
31(5):604-613.
PMID: 29570931
Uveal melanoma (UM) is the most common primary intraocular cancer and has a high incidence of metastasis, which lacks any effective treatment. Here, we present zebrafish models of UM, which...
4.
Wu Q, Zhang J, Koh W, Yu Q, Zhu X, Amsterdam A, et al.
FASEB J
. 2015 Aug;
29(12):4989-5005.
PMID: 26310270
Talin (tln) binds and activates integrins to couple extracellular matrix-bound integrins to the cytoskeleton; however, its role in heart development is not well characterized. We identified the defective gene and...
5.
Percival S, Thomas H, Amsterdam A, Carroll A, Lees J, Yost H, et al.
Dis Model Mech
. 2015 Jun;
8(8):941-55.
PMID: 26044958
Mutations in ESCO2, one of two establishment of cohesion factors necessary for proper sister chromatid cohesion (SCC), cause a spectrum of developmental defects in the autosomal-recessive disorder Roberts syndrome (RBS),...
6.
Jevtov I, Samuelsson T, Yao G, Amsterdam A, Ribbeck K
Sci Rep
. 2014 Oct;
4:6653.
PMID: 25323747
Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in...
7.
Zhang G, Hoersch S, Amsterdam A, Whittaker C, Beert E, Catchen J, et al.
PLoS Genet
. 2013 Sep;
9(8):e1003734.
PMID: 24009526
The identification of cancer drivers is a major goal of current cancer research. Finding driver genes within large chromosomal events is especially challenging because such alterations encompass many genes. Previously,...
8.
Mosimann C, Puller A, Lawson K, Tschopp P, Amsterdam A, Zon L
Dev Dyn
. 2013 Jun;
242(8):949-963.
PMID: 23723152
Background: Linear DNA-based and Tol2-mediated transgenesis are powerful tools for the generation of transgenic zebrafish. However, the integration of multiple copies or transgenes at random genomic locations complicates comparative transgene...
9.
Amsterdam A, Varshney G, Burgess S
Methods Cell Biol
. 2011 Sep;
104:59-82.
PMID: 21924157
Since the initial publication of this chapter in 2004, additional methodologies have been developed which could improve and/or complement the original retroviral-mediated insertional mutagenesis. Retroviral vectors have also been shown...
10.
Thakur P, Stuckenholz C, Rivera M, Davison J, Yao J, Amsterdam A, et al.
Hepatology
. 2011 Apr;
54(2):452-62.
PMID: 21488074
Unlabelled: Hepatic steatosis is the initial stage of nonalcoholic fatty liver disease (NAFLD) and may predispose to more severe hepatic disease, including hepatocellular carcinoma. Endoplasmic reticulum (ER) stress has been...