Ada Sacchi
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Explore the profile of Ada Sacchi including associated specialties, affiliations and a list of published articles.
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59
Citations
2181
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Recent Articles
11.
Nucera C, Muzzi P, Tiveron C, Farsetti A, La Regina F, Foglio B, et al.
J Cell Mol Med
. 2009 Oct;
14(10):2417-35.
PMID: 19863697
Even though several studies highlighted the role of maternal thyroid hormones (THs) during embryo-foetal development, direct evidence of their interaction with embryonic thyroid receptors (TRs) is still lacking. We generated...
12.
Puca R, Nardinocchi L, Sacchi A, Rechavi G, Givol D, DOrazi G
Mol Cancer
. 2009 Oct;
8:85.
PMID: 19828042
Background: Activation of p53-mediated gene transcription is a critical cellular response to DNA damage and involves a phosphorylation-acetylation cascade of p53. The discovery of differences in the response to different...
13.
Nardinocchi L, Puca R, Sacchi A, Rechavi G, Givol D, DOrazi G
PLoS One
. 2009 Aug;
4(8):e6819.
PMID: 19714248
Background: The tumor suppressor homeodomain-interacting protein kinase-2 (HIPK2) by phosphorylating serine 46 (Ser46) is a crucial regulator of p53 apoptotic function. HIPK2 is also a transcriptional co-repressor of hypoxia-inducible factor-1alpha...
14.
Rinaldo C, Prodosmo A, Siepi F, Moncada A, Sacchi A, Selivanova G, et al.
Cancer Res
. 2009 Jul;
69(15):6241-8.
PMID: 19638586
In the past few years, much effort has been devoted to show the single-target specificity of nongenotoxic, p53 reactivating compounds. However, the divergent biological responses induced by the different compounds,...
15.
Manni I, Artuso S, Careccia S, Rizzo M, Baserga R, Piaggio G, et al.
FASEB J
. 2009 Jul;
23(11):3957-66.
PMID: 19608627
MicroRNAs (miRs) are 21- to 23-nucleotide RNA molecules that regulate the stability or translational efficiency of target messenger RNAs of proteins involved in cell growth and apoptosis. miR-92 is part...
16.
Bon G, Di Carlo S, Folgiero V, Avetrani P, Lazzari C, DOrazi G, et al.
Cancer Res
. 2009 Jul;
69(14):5978-86.
PMID: 19567674
Increased expression of alpha(6)beta(4) integrin in several epithelial cancers promotes tumor progression; however, the mechanism underlying its transcriptional regulation remains unclear. Here, we show that depletion of homeodomain-interacting protein kinase...
17.
Mancini F, Di Conza G, Pellegrino M, Rinaldo C, Prodosmo A, Giglio S, et al.
EMBO J
. 2009 Jun;
28(13):1926-39.
PMID: 19521340
MDM4 is a key regulator of p53, whose biological activities depend on both transcriptional activity and transcription-independent mitochondrial functions. MDM4 binds to p53 and blocks its transcriptional activity; however, the...
18.
Nanni S, Benvenuti V, Grasselli A, Priolo C, Aiello A, Mattiussi S, et al.
J Clin Invest
. 2009 Apr;
119(5):1093-108.
PMID: 19363294
The identification of biomarkers that distinguish between aggressive and indolent forms of prostate cancer (PCa) is crucial for diagnosis and treatment. In this study, we used cultured cells derived from...
19.
Marampon F, Bossi G, Ciccarelli C, Di Rocco A, Sacchi A, Pestell R, et al.
Mol Cancer Ther
. 2009 Mar;
8(3):543-51.
PMID: 19258428
We reported previously that the disruption of c-Myc through mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) inhibition blocks the expression of the transformed phenotype in the embryonal rhabdomyosarcoma (ERMS)...
20.
Nardinocchi L, Puca R, Sacchi A, DOrazi G
Mol Cancer
. 2009 Jan;
8:1.
PMID: 19128456
Background: Homeodomain-interacting protein kinase-2 (HIPK2), a transcriptional co-repressor with apoptotic function, can affect hypoxia-inducible factor 1 (HIF-1) transcriptional activity, through downmodulation of its HIF-1alpha subunit, in normoxic condition. Under hypoxia,...