Achala Fernando
Overview
Explore the profile of Achala Fernando including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
33
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Recent Articles
1.
Srinivasan S, Kryza T, Bock N, Tse B, Sokolowski K, Janaththani P, et al.
Nat Commun
. 2024 Nov;
15(1):9587.
PMID: 39505858
Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA)...
2.
Fernando A, Liyanage C, Srinivasan S, Panchadsaram J, Rothnagel J, Clements J, et al.
Commun Med (Lond)
. 2024 Nov;
4(1):224.
PMID: 39487222
Background: Prostate cancer (PCa) is a commonly diagnosed cancer. Genome-wide association studies have implicated Iroquois homeobox 4 (IRX4) in PCa susceptibility, yet its functional roles remain unclear. We discovered a...
3.
Liyanage C, Fernando A, Chamberlain A, Moradi A, Batra J
Cancers (Basel)
. 2024 Apr;
16(7).
PMID: 38610981
N6-methyladenosine (m6A) methylation, a prevalent epitranscriptomic modification, plays a crucial role in regulating mRNA expression, stability, and translation in mammals. M6A regulators have gained attention for their potential implications in...
4.
Janaththani P, Tevz G, Fernando A, Malik A, Rockstroh A, Kryza T, et al.
Res Sq
. 2023 Dec;
PMID: 38076926
Genome-wide association studies have linked Iroquois-Homeobox 4 (IRX4) as a robust expression quantitative-trait locus associated with prostate cancer (PCa) risk. However, the intricate mechanism and regulatory factors governing IRX4 expression...
5.
Moradi A, Sharma H, Sharma R, Fernando A, Barrero R, Batra J
Int J Mol Sci
. 2022 Oct;
23(20).
PMID: 36293264
Single nucleotide polymorphisms (SNPs) impacting the alternative splicing (AS) process (sQTLs) or isoform expression (iso-eQTL) are implicated as important cancer regulatory elements. To find the sQTL and iso-eQTL, we retrieved...
6.
Fernando A, Liyanage C, Moradi A, Janaththani P, Batra J
Genes (Basel)
. 2021 Apr;
12(5).
PMID: 33919200
Alternative splicing (AS) is tightly regulated to maintain genomic stability in humans. However, tumor growth, metastasis and therapy resistance benefit from aberrant RNA splicing. Iroquois-class homeodomain protein 4 (IRX4) is...
7.
Mungenast F, Fernando A, Nica R, Boghiu B, Lungu B, Batra J, et al.
Genes (Basel)
. 2021 Apr;
12(4).
PMID: 33917241
Progress in cancer research is substantially dependent on innovative technologies that permit a concerted analysis of the tumor microenvironment and the cellular phenotypes resulting from somatic mutations and post-translational modifications....
8.
Liyanage C, Fernando A, Batra J
Cancer Metastasis Rev
. 2019 Nov;
38(3):389-415.
PMID: 31673830
Alternative splicing of precursor mRNA is a key mediator of gene expression regulation leading to greater diversity of the proteome in complex organisms. Systematic sequencing of the human genome and...