Judith Clements
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Explore the profile of Judith Clements including associated specialties, affiliations and a list of published articles.
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35
Citations
1637
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Recent Articles
1.
Srinivasan S, Kryza T, Bock N, Tse B, Sokolowski K, Janaththani P, et al.
Nat Commun
. 2024 Nov;
15(1):9587.
PMID: 39505858
Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA)...
2.
Fernando A, Liyanage C, Srinivasan S, Panchadsaram J, Rothnagel J, Clements J, et al.
Commun Med (Lond)
. 2024 Nov;
4(1):224.
PMID: 39487222
Background: Prostate cancer (PCa) is a commonly diagnosed cancer. Genome-wide association studies have implicated Iroquois homeobox 4 (IRX4) in PCa susceptibility, yet its functional roles remain unclear. We discovered a...
3.
Kooshan Z, Cardenas-Piedra L, Clements J, Batra J
Cancer Lett
. 2024 Aug;
600:217156.
PMID: 39127341
Cancer cells display an altered metabolic phenotype, characterised by increased glycolysis and lactate production, even in the presence of sufficient oxygen - a phenomenon known as the Warburg effect. This...
4.
Janaththani P, Tevz G, Fernando A, Malik A, Rockstroh A, Kryza T, et al.
Res Sq
. 2023 Dec;
PMID: 38076926
Genome-wide association studies have linked Iroquois-Homeobox 4 (IRX4) as a robust expression quantitative-trait locus associated with prostate cancer (PCa) risk. However, the intricate mechanism and regulatory factors governing IRX4 expression...
5.
Davoudi F, Moradi A, Becker T, Lock J, Abbey B, Fontanarosa D, et al.
Curr Treat Options Oncol
. 2023 Aug;
24(10):1451-1471.
PMID: 37561382
Prostate cancer (PCa) is the second most diagnosed malignant neoplasm and is one of the leading causes of cancer-related death in men worldwide. Despite significant advances in screening and treatment...
6.
Srinivasan S, Kryza T, Bock N, Tse B, Sokolowski K, Panchadsaram J, et al.
Res Sq
. 2023 Apr;
PMID: 37034758
Genetic variation at the 19q13.3 locus is linked with prostate cancer susceptibility. The non-synonymous SNP, rs17632542 (c.536T>C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional...
7.
Koistinen H, Kovanen R, Hollenberg M, Dufour A, Radisky E, Stenman U, et al.
IUBMB Life
. 2023 Jan;
75(6):493-513.
PMID: 36598826
Since the proposition of the pro-invasive activity of proteolytic enzymes over 70 years ago, several roles for proteases in cancer progression have been established. About half of the 473 active...
8.
Srinivasan S, Kryza T, Batra J, Clements J
Nat Rev Cancer
. 2022 Feb;
22(4):223-238.
PMID: 35102281
Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment. KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including hormones and growth factors, membrane receptors and the extracellular...
9.
Lin H, Huang P, Cheng C, Tung H, Fang Z, Berglund A, et al.
Sci Rep
. 2021 Apr;
11(1):9264.
PMID: 33927218
Risk classification for prostate cancer (PCa) aggressiveness and underlying mechanisms remain inadequate. Interactions between single nucleotide polymorphisms (SNPs) may provide a solution to fill these gaps. To identify SNP-SNP interactions...
10.
Liyanage C, Malik A, Abeysinghe P, Clements J, Batra J
Cancers (Basel)
. 2021 Feb;
13(4).
PMID: 33572476
Prostate cancer (PCa) is the second most common cancer affecting men worldwide. PCa shows a broad-spectrum heterogeneity in its biological and clinical behavior. Although androgen targeted therapy (ATT) has been...