Abigail J Tomlinson
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Explore the profile of Abigail J Tomlinson including associated specialties, affiliations and a list of published articles.
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8
Citations
36
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Recent Articles
1.
Yacawych W, Wang Y, Zhou G, Hassan S, Kernodle S, Sass F, et al.
bioRxiv
. 2025 Feb;
PMID: 39896596
GLP-1 receptor agonists (GLP1RAs) effectively reduce feeding to treat obesity, although nausea and other aversive side effects of these drugs can limit their use. Brainstem circuits that promote satiation and...
2.
Ludwig M, Coester B, Gordian D, Hassan S, Tomlinson A, Toure M, et al.
bioRxiv
. 2025 Jan;
PMID: 39868309
Amylin analogs, including potential anti-obesity therapies like cagrilintide, act on neurons in the brainstem dorsal vagal complex (DVC) that express calcitonin receptors (CALCR). These receptors, often combined with receptor activity-modifying...
3.
Wang Y, Qiu W, Kernodle S, Parker C, Padilla M, Su J, et al.
Mol Metab
. 2025 Jan;
92:102093.
PMID: 39755369
Objective: Several groups of neurons in the NTS suppress food intake, including Prlh-expressing neurons (NTS cells). Not only does the artificial activation of NTS cells decrease feeding, but also the...
4.
Polex-Wolf J, Deibler K, Hogendorf W, Bau S, Glendorf T, Stidsen C, et al.
Sci Transl Med
. 2024 Dec;
16(776):eadk4908.
PMID: 39630884
Glucagon-like peptide-1 (GLP-1) and leptin signal recent feeding and long-term energy stores, respectively, and play complementary roles in the modulation of energy balance. Previous work using single-cell techniques in mice...
5.
Sass F, Ma T, Ekberg J, Kirigiti M, Urena M, Dollet L, et al.
Nature
. 2024 Nov;
635(8040):987-1000.
PMID: 39537932
The combination of decreasing food intake and increasing energy expenditure represents a powerful strategy for counteracting cardiometabolic diseases such as obesity and type 2 diabetes. Yet current pharmacological approaches require...
6.
Hashsham A, Kodur N, Su J, Tomlinson A, Yacawych W, Flak J, et al.
bioRxiv
. 2024 Jun;
PMID: 38826340
The brain augments glucose production during fasting, but the mechanisms are poorly understood. Here, we show that -expressing neurons in the ventromedial hypothalamic nucleus (VMN cells) prevent low blood glucose...
7.
Rupp A, Tomlinson A, Affinati A, Yacawych W, Duensing A, True C, et al.
J Clin Invest
. 2023 Aug;
133(19).
PMID: 37581939
The adipose-derived hormone leptin acts via its receptor (LepRb) in the brain to control energy balance. A potentially unidentified population of GABAergic hypothalamic LepRb neurons plays key roles in the...
8.
Affinati A, Sabatini P, True C, Tomlinson A, Kirigiti M, Lindsley S, et al.
Elife
. 2021 May;
10.
PMID: 34018926
The ventromedial hypothalamic nucleus (VMH) controls diverse behaviors and physiologic functions, suggesting the existence of multiple VMH neural subtypes with distinct functions. Combing translating ribosome affinity purification with RNA-sequencing (TRAP-seq)...
9.
Wang S, Roy J, Tomlinson A, Wang E, Tsai Y, Cameron L, et al.
Development
. 2020 Sep;
147(20).
PMID: 32994164
Between embryonic days 10.5 and 14.5, active proliferation drives rapid elongation of the murine midgut epithelial tube. Within this pseudostratified epithelium, nuclei synthesize DNA near the basal surface and move...
10.
Barnes T, Shah K, Allison M, Steinl G, Gordian D, Sabatini P, et al.
Mol Metab
. 2020 Feb;
32:168-175.
PMID: 32029227
Background: Leptin acts via its receptor, LepRb, on specialized neurons in the brain to modulate energy balance and glucose homeostasis. LepRb→STAT3 signaling plays a crucial role in leptin action, but...