Abhishek Sampath Kumar
Overview
Explore the profile of Abhishek Sampath Kumar including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
345
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Recent Articles
1.
You Y, Fu Y, Li L, Zhang Z, Jia S, Lu S, et al.
Nat Methods
. 2024 Jul;
21(9):1743-1754.
PMID: 38965443
Recent developments of sequencing-based spatial transcriptomics (sST) have catalyzed important advancements by facilitating transcriptome-scale spatial gene expression measurement. Despite this progress, efforts to comprehensively benchmark different platforms are currently lacking....
2.
Anton-Bolanos N, Faravelli I, Faits T, Andreadis S, Kastli R, Trattaro S, et al.
Nature
. 2024 Jun;
631(8019):142-149.
PMID: 38926573
Interindividual genetic variation affects the susceptibility to and progression of many diseases. However, efforts to study how individual human brains differ in normal development and disease phenotypes are limited by...
3.
Stotzel M, Cheng C, IIik I, Kumar A, Omgba P, van der Weijden V, et al.
Nat Struct Mol Biol
. 2024 May;
31(10):1625-1639.
PMID: 38783076
Dormancy is an essential biological process for the propagation of many life forms through generations and stressful conditions. Early embryos of many mammals are preservable for weeks to months within...
4.
Sato N, Rosa V, Makhlouf A, Kretzmer H, Kumar A, Grosswendt S, et al.
Dev Cell
. 2024 Apr;
59(10):1252-1268.e13.
PMID: 38579720
The blueprint of the mammalian body plan is laid out during gastrulation, when a trilaminar embryo is formed. This process entails a burst of proliferation, the ingression of embryonic epiblast...
5.
Ravid Lustig L, Kumar A, Schwammle T, Dunkel I, Noviello G, Limberg E, et al.
Nat Cell Biol
. 2023 Nov;
25(11):1704-1715.
PMID: 37932452
X-chromosome inactivation (XCI) balances gene expression between the sexes in female mammals. Shortly after fertilization, upregulation of Xist RNA from one X chromosome initiates XCI, leading to chromosome-wide gene silencing....
6.
Kumar A, Tian L, Bolondi A, Hernandez A, Stickels R, Kretzmer H, et al.
Nat Genet
. 2023 Jul;
55(7):1176-1185.
PMID: 37414952
Spatiotemporal orchestration of gene expression is required for proper embryonic development. The use of single-cell technologies has begun to provide improved resolution of early regulatory dynamics, including detailed molecular definitions...
7.
Weigert R, Hetzel S, Bailly N, Haggerty C, Ilik I, Yung P, et al.
Nat Cell Biol
. 2023 Apr;
25(4):579-591.
PMID: 37024684
DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and operate within distinct genomic compartments. In mammals, the majority of the genome is kept in a DNA...
8.
Asimi V, Kumar A, Niskanen H, Riemenschneider C, Hetzel S, Naderi J, et al.
Nat Genet
. 2022 Jul;
54(8):1238-1247.
PMID: 35864192
Most endogenous retroviruses (ERVs) in mammals are incapable of retrotransposition; therefore, why ERV derepression is associated with lethality during early development has been a mystery. Here, we report that rapid...
9.
Pour M, Kumar A, Farag N, Bolondi A, Kretzmer H, Walther M, et al.
iScience
. 2022 Jan;
25(1):103556.
PMID: 34988400
The segregation of definitive endoderm (DE) from bipotent mesendoderm progenitors leads to the formation of two distinct germ layers. Dissecting DE commitment and onset has been challenging as it occurs...
10.
Haggerty C, Kretzmer H, Riemenschneider C, Kumar A, Mattei A, Bailly N, et al.
Nat Struct Mol Biol
. 2021 Jun;
28(7):594-603.
PMID: 34140676
DNA methylation plays a critical role during development, particularly in repressing retrotransposons. The mammalian methylation landscape is dependent on the combined activities of the canonical maintenance enzyme Dnmt1 and the...