David Meierhofer
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Explore the profile of David Meierhofer including associated specialties, affiliations and a list of published articles.
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Articles
90
Citations
1974
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Recent Articles
1.
Kopp J, Jahn D, Vogt G, Psoma A, Ratto E, Morelle W, et al.
Cell Mol Life Sci
. 2024 Dec;
82(1):4.
PMID: 39680136
Loss-of-function variants in ATP6V0A2, encoding the trans Golgi V-ATPase subunit V0a2, cause wrinkly skin syndrome (WSS), a connective tissue disorder with glycosylation defects and aberrant cortical neuron migration. We used...
2.
Guo J, Krehl K, Safraou Y, Wallach I, Braun J, Meierhofer D, et al.
Heliyon
. 2024 Nov;
10(20):e39674.
PMID: 39506943
Pregnancy places a metabolic burden on the body including the liver, which is responsible for ensuring adequate nutrition for the maternal and fetal systems. To gain a better understanding of...
3.
Tsaytler P, Blaess G, Scholze-Wittler M, Meierhofer D, Wittler L, Koch F, et al.
Cell Rep
. 2024 Oct;
43(10):114846.
PMID: 39392751
Serum response factor (SRF) is a transcription factor essential for cell proliferation, differentiation, and migration and is required for primitive streak and mesoderm formation in the embryo. The canonical roles...
4.
Eden J, Thorne A, Bodewes S, Patrono D, Roggio D, Breuer E, et al.
J Hepatol
. 2024 Sep;
82(3):523-534.
PMID: 39251091
Background & Aims: While it is currently assumed that liver assessment is only possible during normothermic machine perfusion, there is uncertainty regarding a reliable and quick prediction of graft injury...
5.
Lisowski P, Lickfett S, Rybak-Wolf A, Menacho C, Le S, Pentimalli T, et al.
Nat Commun
. 2024 Aug;
15(1):7027.
PMID: 39174523
Expansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington's disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain...
6.
Borisova E, Newman A, Couce Iglesias M, Dannenberg R, Schaub T, Qin B, et al.
Nat Commun
. 2024 Jun;
15(1):4879.
PMID: 38849354
The mammalian neocortex comprises an enormous diversity regarding cell types, morphology, and connectivity. In this work, we discover a post-transcriptional mechanism of gene expression regulation, protein translation, as a determinant...
7.
Ulicevic J, Shao Z, Jasnovidova O, Bressin A, Gajos M, Ng A, et al.
Mol Syst Biol
. 2024 May;
20(7):767-798.
PMID: 38755290
Static gene expression programs have been extensively characterized in stem cells and mature human cells. However, the dynamics of RNA isoform changes upon cell-state-transitions during cell differentiation, the determinants and...
8.
Kudrin P, Singh A, Meierhofer D, Kusnierczyk A, Vang Orom U
EMBO Rep
. 2024 Feb;
25(4):1814-1834.
PMID: 38413733
Stress granules are an integral part of the stress response that are formed from non-translating mRNAs aggregated with proteins. While much is known about stress granules, the factors that drive...
9.
Key J, Gispert S, Kandi A, Heinz D, Hamann A, Osiewacz H, et al.
Biomolecules
. 2024 Feb;
14(2).
PMID: 38397478
The serine peptidase CLPP is conserved among bacteria, chloroplasts, and mitochondria. In humans and mice, its loss causes Perrault syndrome, which presents with growth deficits, infertility, deafness, and ataxia. In...
10.
Ilik I, Glazar P, Tse K, Brandl B, Meierhofer D, Muller F, et al.
Nature
. 2024 Feb;
626(8001):1116-1124.
PMID: 38355802
Transposable elements (TEs) are a major constituent of human genes, occupying approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs are transcribed along with their host genes...