Francois Van Laethem
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Explore the profile of Francois Van Laethem including associated specialties, affiliations and a list of published articles.
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27
Citations
1201
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Recent Articles
1.
Van Laethem F, Donaty L, Tchernonog E, Lacheretz-Szablewski V, Russello J, Buthiau D, et al.
Int J Mol Sci
. 2022 Dec;
23(24).
PMID: 36555775
Leukocyte-associated immunoglobulin (Ig)-like receptor 1 (LAIR1, CD305) belongs to the family of immune-inhibitory receptors and is widely expressed on hematopoietic mature cells, particularly on immune cells. Four different types of...
2.
Van Laethem F, Bhattacharya A, Craveiro M, Lu J, Sun P, Singer A
Front Immunol
. 2022 Aug;
13:953160.
PMID: 35911724
Understanding the generation of an MHC-restricted T cell repertoire is the cornerstone of modern T cell immunology. The unique ability of αβT cells to only recognize peptide antigens presented by...
3.
Lamure S, Van Laethem F, de Verbizier D, Lozano C, Gehlkopf E, Tudesq J, et al.
Cancers (Basel)
. 2021 Sep;
13(17).
PMID: 34503088
CD19-directed CAR T-cells have been remarkably successful in treating patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and transformed follicular lymphoma (t-FL). In this cohort study, we treated 60...
4.
Maqbool M, Pioger L, El Aabidine A, Karasu N, Molitor A, Dao L, et al.
Cell Rep
. 2020 Aug;
32(7):108048.
PMID: 32814051
During thymic development and upon peripheral activation, T cells undergo extensive phenotypic and functional changes coordinated by lineage-specific developmental programs. To characterize the regulatory landscape controlling T cell identity, we...
5.
Van Laethem F, Saba I, Lu J, Bhattacharya A, Tai X, Guinter T, et al.
Front Immunol
. 2020 Jul;
11:1216.
PMID: 32612609
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered...
6.
Lu J, Van Laethem F, Saba I, Chu J, Tikhonova A, Bhattacharya A, et al.
J Immunol
. 2020 Apr;
204(12):3351-3359.
PMID: 32321756
During normal T cell development in the thymus, αβ TCRs signal immature thymocytes to differentiate into mature T cells by binding to peptide-MHC ligands together with CD4/CD8 coreceptors. Conversely, in...
7.
Lu J, Van Laethem F, Bhattacharya A, Craveiro M, Saba I, Chu J, et al.
Nat Commun
. 2019 Mar;
10(1):1019.
PMID: 30833553
The αβ T cell receptor (TCR) repertoire on mature T cells is selected in the thymus, but the basis for thymic selection of MHC-restricted TCRs from a randomly generated pre-selection...
8.
Harrison O, Linehan J, Shih H, Bouladoux N, Han S, Smelkinson M, et al.
Science
. 2018 Dec;
363(6422).
PMID: 30523076
Barrier tissues are primary targets of environmental stressors and are home to the largest number of antigen-experienced lymphocytes in the body, including commensal-specific T cells. We found that skin-resident commensal-specific...
9.
Madi A, Poran A, Shifrut E, Reich-Zeliger S, Greenstein E, Zaretsky I, et al.
Elife
. 2017 Jul;
6.
PMID: 28731407
Diversity of T cell receptor (TCR) repertoires, generated by somatic DNA rearrangements, is central to immune system function. However, the level of sequence similarity of TCR repertoires within and between...
10.
Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, et al.
Nat Immunol
. 2015 Aug;
16(10):1069-76.
PMID: 26301566
In the thymus, low-affinity T cell antigen receptor (TCR) engagement facilitates positive selection of a useful T cell repertoire. Here we report that TCR responsiveness of mature CD8(+) T cells...