Abdu I Alayash
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Explore the profile of Abdu I Alayash including associated specialties, affiliations and a list of published articles.
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113
Citations
2728
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Recent Articles
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Alayash A
Antioxidants (Basel)
. 2022 Apr;
11(4).
PMID: 35453432
Hemoglobin (Hb) inside and outside the red blood cells (RBCs) undergoes constant transformation to an oxidized form in a process known as autoxidation. The ferrous heme iron (Fe) of the...
13.
Quezado Z, Kamimura S, Smith M, Wang X, Heaven M, Jana S, et al.
Blood Cells Mol Dis
. 2022 Apr;
95:102660.
PMID: 35366607
Polymerization of deoxygenated sickle hemoglobin (HbS) leads to erythrocyte sickling. Enhancing activity of the erythrocyte glycolytic pathway has anti-sickling potential as this reduces 2,3-diphosphoglycerate (2,3-DPG) and increases ATP, factors that...
14.
Alayash A
Front Physiol
. 2021 Oct;
12:711976.
PMID: 34690793
The novel coronavirus (2019-nCoV/SARS-CoV-2) causes respiratory symptoms including a substantial pulmonary dysfunction with worsening arterial hypoxemia (low blood oxygenation), eventually leading to acute respiratory distress syndrome (ARDS). The impact of...
15.
Kassa T, Whalin J, Richards M, Alayash A
FEBS Open Bio
. 2021 Sep;
11(12):3293-3303.
PMID: 34510823
It is well documented that caffeic acid (3,4-dihydroxycinnamic acid) (CA) interacts with and inhibits the oxidative reactions of myoglobin (Mb) and hemoglobin (Hb), and this interaction underlies its antioxidative action...
16.
Jana S, Heaven M, Alayash A
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445747
SARS-CoV-2 primarily infects epithelial airway cells that express the host entry receptor angiotensin-converting enzyme 2 (ACE2), which binds to the S1 spike protein on the surface of the virus. To...
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18.
Jana S, Strader M, Alayash A
Int J Mol Sci
. 2020 Dec;
21(24).
PMID: 33322551
The highly toxic oxidative transformation of hemoglobin (Hb) to the ferryl state (HbFe) is known to occur in both in vitro and in vivo settings. We recently constructed oxidatively stable...
19.
Hicks W, Meng F, Kassa T, Alayash A
Redox Rep
. 2020 Oct;
25(1):95-103.
PMID: 33059548
The β subunit substitutions, F41Y and K82D, in sickle cell hemoglobin (Hb) (βE6 V) provides significant resistance to oxidative stress by shielding βCys93 from the oxidizing ferryl heme. We evaluated...
20.
Alayash A
Lab Invest
. 2020 Sep;
101(1):4-11.
PMID: 32980855
βcysteine 93 residue plays a key role in oxygen (O)-linked conformational changes in the hemoglobin (Hb) molecule. This solvent accessible residue is also a target for binding of thiol reagents...