Michael Brad Strader
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Explore the profile of Michael Brad Strader including associated specialties, affiliations and a list of published articles.
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29
Citations
466
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Recent Articles
1.
Distinct proteomes and allergen profiles appear across the life-cycle stages of Alternaria alternata
Strader M, Saha A, Fernandes C, Sharma K, Hadiwinarta C, Calheiros D, et al.
J Allergy Clin Immunol
. 2024 Apr;
154(2):424-434.
PMID: 38663817
Background: Alternaria alternata is associated with allergic respiratory diseases, which can be managed with allergen extract-based diagnostics and immunotherapy. It is not known how spores and hyphae contribute to allergen...
2.
Jana S, Strader M, Alayash A
Int J Mol Sci
. 2020 Dec;
21(24).
PMID: 33322551
The highly toxic oxidative transformation of hemoglobin (Hb) to the ferryl state (HbFe) is known to occur in both in vitro and in vivo settings. We recently constructed oxidatively stable...
3.
Strader M, Jana S, Meng F, Heaven M, Shet A, Thein S, et al.
Sci Rep
. 2020 Aug;
10(1):14218.
PMID: 32848178
Intracellular oxidative stress and oxidative modification of sickle hemoglobin (HbS) play a role in sickle cell disease (SCD) pathogenesis. Recently, we reported that Hb-dependent oxidative stress induced post-translational modifications (PTMs)...
4.
Kassa T, Wood F, Strader M, Alayash A
Front Physiol
. 2019 Aug;
10:931.
PMID: 31396101
Sickle cell disease is a genetic blood disorder caused by a single point mutation in the β globin gene where glutamic acid is replaced by valine at the sixth position...
5.
Edmondson M, Jana S, Meng F, Strader M, Baek J, Gao Y, et al.
Free Radic Biol Med
. 2019 Jul;
141:348-361.
PMID: 31302228
Cardiovascular effects were reported to occur in humans and in animal models during transfusion with hemoglobin (Hb)-based oxygen therapeutics. The effects of Hb's iron redox states on cardiac parameters during...
6.
Strader M, Liang H, Meng F, Harper J, Ostrowski D, Henry E, et al.
Bioconjug Chem
. 2019 Feb;
30(3):568-571.
PMID: 30794381
The pathophysiology associated with sickle cell disease (SCD) includes hemolytic anemia, vaso-occlusive events, and ultimately end organ damage set off by the polymerization of deoxygenated hemoglobin S (HbS) into long...
7.
Meng F, Kassa T, Strader M, Soman J, Olson J, Alayash A
J Biol Chem
. 2019 Jan;
294(11):4145-4159.
PMID: 30630954
After reacting with hydrogen peroxide (HO), sickle-cell hemoglobin (HbS, βE6V) remains longer in a highly oxidizing ferryl form (HbFe=O) and induces irreversible oxidation of "hot-spot" amino acids, including βCys-93. To...
8.
Jana S, Strader M, Meng F, Hicks W, Kassa T, Tarandovskiy I, et al.
JCI Insight
. 2018 Nov;
3(21).
PMID: 30385713
The contribution of intracellular hemoglobin (Hb) oxidation to RBC-derived microparticle (MP) formation is poorly defined in sickle cell disease (SCD). Here we report that sickle Hb (HbS) oxidation, coupled with...
9.
Kettisen K, Strader M, Wood F, Alayash A, Bulow L
Redox Biol
. 2018 Sep;
19:218-225.
PMID: 30193183
Redox active cysteine residues including βCys93 are part of hemoglobin's "oxidation hotspot". Irreversible oxidation of βCys93 ultimately leads to the collapse of the hemoglobin structure and release of heme. Human...
10.
Strader M, Bangle R, Parker Siburt C, Varnado C, Soman J, Benitez Cardenas A, et al.
Biochem J
. 2017 Oct;
474(24):4171-4192.
PMID: 29070524
Previous work suggested that hemoglobin (Hb) tetramer formation slows autoxidation and hemin loss and that the naturally occurring mutant, Hb Providence (HbProv; βK82D), is much more resistant to degradation by...