Abdelghani Mazouzi
Overview
Explore the profile of Abdelghani Mazouzi including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
382
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0
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Recent Articles
1.
Manzo S, Mazouzi A, Leemans C, van Schaik T, Neyazi N, van Ruiten M, et al.
EMBO J
. 2024 Sep;
43(21):5260-5287.
PMID: 39322756
Lamina-associated domains (LADs) are large chromatin regions that are associated with the nuclear lamina (NL) and form a repressive environment for transcription. The molecular players that mediate gene repression in...
2.
Mazouzi A, Moser S, Abascal F, van den Broek B, Del Castillo Velasco-Herrera M, van der Heijden I, et al.
Sci Adv
. 2023 May;
9(22):eadf4409.
PMID: 37256941
DNA interstrand crosslinks (ICLs) pose a major obstacle for DNA replication and transcription if left unrepaired. The cellular response to ICLs requires the coordination of various DNA repair mechanisms. Homologous...
3.
Nordgaard C, Vind A, Stonadge A, Kjobsted R, Snieckute G, Antas P, et al.
EMBO J
. 2022 Jul;
41(17):e111650.
PMID: 35899396
Mechanical inputs give rise to p38 and JNK activation, which mediate adaptive physiological responses in various tissues. In skeletal muscle, contraction-induced p38 and JNK signaling ensure adaptation to exercise, muscle...
4.
Mazouzi A, Battistini F, Moser S, Ferreira da Silva J, Wiedner M, Owusu M, et al.
Mol Cell
. 2017 Nov;
68(4):797-807.e7.
PMID: 29149600
DNA lesions caused by UV damage are thought to be repaired solely by the nucleotide excision repair (NER) pathway in human cells. Patients carrying mutations within genes functioning in this...
5.
Nieuwenhuis J, Adamopoulos A, Bleijerveld O, Mazouzi A, Stickel E, Celie P, et al.
Science
. 2017 Nov;
358(6369):1453-1456.
PMID: 29146869
Tubulin is subjected to a number of posttranslational modifications to generate heterogeneous microtubules. The modifications include removal and ligation of the C-terminal tyrosine of ⍺-tubulin. The enzymes responsible for detyrosination,...
6.
Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, et al.
Nat Commun
. 2017 Nov;
8(1):1238.
PMID: 29089570
Maintenance of genome integrity via repair of DNA damage is a key biological process required to suppress diseases, including Fanconi anemia (FA). We generated loss-of-function human haploid cells for FA...
7.
Smida M, Fece de la Cruz F, Kerzendorfer C, Uras I, Mair B, Mazouzi A, et al.
Nat Commun
. 2016 Dec;
7:13701.
PMID: 27922010
Lung cancer is the leading cause of cancer deaths, and effective treatments are urgently needed. Loss-of-function mutations in the DNA damage response kinase ATM are common in lung adenocarcinoma but...
8.
Mazouzi A, Stukalov A, Muller A, Chen D, Wiedner M, Prochazkova J, et al.
Cell Rep
. 2016 May;
15(4):893-908.
PMID: 27149854
The cellular response to replication stress requires the DNA-damage-responsive kinase ATM and its cofactor ATMIN; however, the roles of this signaling pathway following replication stress are unclear. To identify the...
9.
Prochazkova J, Sakaguchi S, Owusu M, Mazouzi A, Wiedner M, Velimezi G, et al.
PLoS Genet
. 2015 Nov;
11(11):e1005645.
PMID: 26544571
Proper development of the immune system is an intricate process dependent on many factors, including an intact DNA damage response. The DNA double-strand break signaling kinase ATM and its cofactor...
10.
Wang Z, Yang X, Mazouzi A, Ramotar D
Gene
. 2014 Oct;
553(2):151-7.
PMID: 25307766
We previously isolated from a Caenorhabditis elegans cDNA library, designed for two-hybrid screening, a gene encoding the DNA repair enzyme APN-1 using cross-specie complementation analysis of the Saccharomyces cerevisiae apn1∆...